Identification of the metabolites of baicalein in human plasma
Identification of the metabolites of baicalein in human plasma
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DOI：
10.1080/10286020.2011.599321
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发表时间：
2011-01-01
影响因子：
1.7
通讯作者：
Che, Qing-Ming
中科院分区：
文献类型：
--
作者：
Guo, Xiao-Yu;Yang, Lin;Che, Qing-Ming
研究了黄芩素在人体内的代谢产物，黄芩素是黄芩中的主要活性黄酮之一。采用高效液相色谱-二极管阵列检测器（HPLC-DAD）和液相色谱-串联质谱（LC-MS/MS）联用技术，检测并鉴定了5个代谢产物（M1-M5）和母体药物黄芩素（P）。其中，7-甲氧基黄芩素6-O-葡萄糖醛酸苷（M5）为新代谢产物。根据结果，推测了黄芩素在人体内的拟议代谢途径。
The metabolites of baicalein in human plasma were investigated after taking baicalein, which is one of the main bioactive flavones in Scutellaria baicalensis Georgi. Five metabolites (M1-M5) together with the parent drug baicalein (P) were detected and identified by the HPLC-diode-array detector (DAD) and LC-MS/MS methods. Among them, 7-methoxybaicalein 6-O-glucuronide (M5) is a new metabolite. Based on the results, the proposed metabolic pathway of baicalein in humans was inferred.