Zebrafish: a model system for the study of human disease
Zebrafish: a model system for the study of human disease
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DOI：
10.1016/s0959-437x(00)00074-5
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发表时间：
2000-06-01
影响因子：
4
通讯作者：
Zon, LI
中科院分区：
文献类型：
--
作者：
Dooley, K;Zon, LI
斑马鱼（Danio rerio）是脊椎动物生物学研究的重要模式生物，非常适合于发育和遗传分析。大规模的基因筛选已经确定了数百种突变表型，其中许多类似于人类临床疾病。关键基因试剂的创建，再加上由美国国立卫生研究院指导的斑马鱼基因组计划的快速进展，正在使该模型系统充分发挥其在脊椎动物生物学，生理学和人类疾病研究中的潜力。
The zebrafish (Danio rerio) is a powerful model organism for the study of vertebrate biology, being well suited to both developmental and genetic analysis. Large-scale genetic screens have identified hundreds of mutant phenotypes, many of which resemble human clinical disorders. The creation of critical genetic reagents, coupled with the rapid progress of the zebrafish genome initiative directed by the National Institutes of Health, are bringing this model system to its full potential for the study of vertebrate biology, physiology and human disease.