The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds.
The Human Cathelicidin Antimicrobial Peptide LL-37 as a Potential Treatment for Polymicrobial Infected Wounds.
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DOI：
10.3389/fimmu.2013.00143
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发表时间：
2013
影响因子：
7.3
通讯作者：
van Hoek ML
中科院分区：
文献类型：
--
作者：
Duplantier AJ;van Hoek ML
糖尿病患者的下肢经常有溃疡，这些溃疡被多种生物膜形成细菌属感染，并且生物膜的消除已被证明在解决患者的此类伤口方面非常成功。为此，抗微生物肽已显示出作为新的抗生物膜方法的潜力。单一人凯萨林菌素肽LL-37已显示出对多种革兰氏阳性和革兰氏阴性人病原体具有抗微生物和抗生物膜活性，并且对宿主具有伤口愈合作用。LL-37的抗生物膜作用和伤口愈合特性的组合可以使其在局部施用时在解决多种微生物感染的伤口方面非常有效。这样的肽或其衍生物可以是开发新的治疗策略以治疗生物膜介导的伤口感染的平台。这篇综述总结了已知的机制，调节内源性水平的LL-37，并讨论了抗生物膜，抗菌和免疫效果的不足与过度浓度的LL-37在伤口环境。在这里，我们回顾了最近的进展，了解这种肽和其他临床先进的肽作为一个潜在的局部治疗多微生物感染的伤口的治疗潜力。
Diabetic patients often have ulcers on their lower-limbs that are infected by multiple biofilm-forming genera of bacteria, and the elimination of the biofilm has proven highly successful in resolving such wounds in patients. To that end, antimicrobial peptides have shown potential as a new anti-biofilm approach. The single human cathelicidin peptide LL-37 has been shown to have antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and have wound-healing effects on the host. The combination of the anti-biofilm effect and wound-healing properties of LL-37 may make it highly effective in resolving polymicrobially infected wounds when topically applied. Such a peptide or its derivatives could be a platform from which to develop new therapeutic strategies to treat biofilm-mediated infections of wounds. This review summarizes known mechanisms that regulate the endogenous levels of LL-37 and discusses the anti-biofilm, antibacterial, and immunological effects of deficient vs. excessive concentrations of LL-37 within the wound environment. Here, we review recent advances in understanding the therapeutic potential of this peptide and other clinically advanced peptides as a potential topical treatment for polymicrobial infected wounds.