Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
Heartbeat regulates cardiogenesis by suppressing retinoic acid signaling via expression of miR-143
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DOI：
10.1016/j.mod.2010.09.002
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发表时间：
2011-02
影响因子：
2.6
通讯作者：
K. Miyasaka;Yasuyuki S. Kida;Toshihiro Banjo;Y. Ueki;K. Nagayama;Takeo Matsumoto;Masaaki Sato;T. Ogura
中科院分区：
文献类型：
--
作者：
K. Miyasaka;Yasuyuki S. Kida;Toshihiro Banjo;Y. Ueki;K. Nagayama;Takeo Matsumoto;Masaaki Sato;T. Ogura
心脏发生伴随着血流动力学的变化，以适应发育中器官和组织的循环需求。在成年人中，循环适应对于血液循环的稳态调节至关重要。在这些依赖血液动力学的形态发生和适应过程中，将机械刺激转化为生物输出的机械转导途径起着重要作用，尽管其分子性质在很大程度上是未知的。在这里，我们报告斑马鱼miR-143的表达依赖于心跳。敲低miR-143导致视黄酸信号的去抑制，并在流出道和心室中产生异常。我们的数据揭示了心跳和心脏发育之间的一种新的表观遗传联系，miR-143是机械转导级联反应的重要组成部分。
Cardiogenesis proceeds with concomitant changes in hemodynamics to accommodate the circulatory demands of developing organs and tissues. In adults, circulatory adaptation is critical for the homeostatic regulation of blood circulation. In these hemodynamics-dependent processes of morphogenesis and adaptation, a mechanotransduction pathway, which converts mechanical stimuli into biological outputs, plays an essential role, although its molecular nature is largely unknown. Here, we report that expression of zebrafish miR-143 is dependent on heartbeat. Knocking-down miR-143 results in de-repression of retinoic acid signaling, and produces abnormalities in the outflow tracts and ventricles. Our data uncover a novel epigenetic link between heartbeat and cardiac development, with miR-143 as an essential component of the mechanotransduction cascade.