The relevance of differential response to trauma in an animal model of posttraumatic stress disorder
The relevance of differential response to trauma in an animal model of posttraumatic stress disorder
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DOI：
10.1016/s0006-3223(02)01909-1
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发表时间：
2003-03-15
影响因子：
10.6
通讯作者：
Matar, M
中科院分区：
文献类型：
--
作者：
Cohen, H;Zohar, J;Matar, M
背景：创伤后应激障碍影响了20%-30%的暴露者。临床研究采用严格的纳入-排除标准，但动物研究将整个暴露人群作为研究人群。我们研究的效果分组预应力大鼠根据响应的大小上的统计分析results.Method：捕食者暴露的响应幅度进行了评估，并用于分组的动物成“诊断”组。使用任意选择的截止行为标准（CBC）研究了两个极端（明显“适应不良”和明显“适应良好”的大鼠）。为了清楚起见，中间组的数据被丢弃。下丘脑-垂体-肾上腺轴和心率变异性进行了分析，为整个暴露人群，然后根据CBC.Results：一个单一的10分钟暴露于捕食者引起的恐惧相关的行为，只有25.3%的暴露大鼠。与对照组和适应良好的暴露大鼠相比，适应不良的大鼠表现出显着更高的血浆皮质酮和促肾上腺皮质激素浓度，增加交感神经活性，减少迷走神经张力，增加交感迷走神经平衡。这些差异浮出水面，只有当数据进行了分析，根据CBC.Conclusions：动物对压力的异质性，类似于人类。忽略这种异质性可能会掩盖数据分析的结果。动物可以根据反应的大小分为不同的组，并进行相应的研究。(C)2003年生物精神病学学会
Background: Posttraumatic stress disorder affects 20%-30% of those exposed. Clinical studies employ stringent inclusion-exclusion criteria, yet animal studies include the entire exposed population as the study population. We examined the effect of grouping prestressed rats according to magnitude of response on the statistical analysis of results.Method: Response magnitude to predator exposure was assessed and used to group the animals into "diagnostic" groups. Two extremes were studied (clearly "maladapted" and clearly "well adapted" rats) using arbitrarily selected cutoff behavioral criteria (CBC). The data for the middle group were discarded for reasons of clarity. Hypothalamic-pituitary-adrenal axis and heart-rate variability were analyzed for the entire exposed population and then according to the CBC.Results: A single 10-min exposure to a predator caused fear-related behaviors in only 25.3% of exposed rats. Compared with control subjects and well-adapted exposed rats, maladapted rats exhibited significantly higher plasma corticosterone and corticotropin concentrations, increased sympathetic activity, diminished vagal tone, and increased sympathovagal balance. These differences surfaced only when data were analyzed according to CBC.Conclusions: Animals respond to stress heterogeneously, resembling humans. Overlooking this heterogeneity may obscure the results of data analysis. Animals can be divided into distinct groups according to magnitude of response and be studied accordingly. (C) 2003 Society of Biological Psychiatry