Fludarabine is effective in the treatment of splenic lymphoma with villous lymphocytes
Fludarabine is effective in the treatment of splenic lymphoma with villous lymphocytes
复制标题
氟达拉滨治疗绒毛淋巴细胞脾淋巴瘤有效
DOI：
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发表时间：
1997
影响因子：
6.5
通讯作者：
D. Oscier
中科院分区：
文献类型：
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作者：
S. Bolam;J. Orchard;D. Oscier
我们报告了四名患有绒毛淋巴细胞脾淋巴瘤（SLVL）患者使用氟达拉滨的情况。所有四人均在推荐的一线治疗后复发或无反应。在每种情况下，氟达拉滨都产生了完整的临床血液学反应，且毒性最小，在两名患者的长期随访中证明这种反应是持久的。氟达拉滨可有效治疗 SLVL，应被视为一线治疗选择和挽救治疗。
We report on the use of fludarabine in four patients with splenic lymphoma with villous lymphocytes (SLVL). All four had relapsed after, or failed to respond to, recommended first‐line therapies. In each case fludarabine resulted in a complete clinico‐haematological response with minimal toxicity, which, in the two patients with long‐term follow‐up, proved durable. Fludarabine is effective in the treatment of SLVL and should be considered as both a first‐line therapeutic option as well as salvage therapy in this condition.