Interstitial stem cells in Hydra: multipotency and decision-making
Interstitial stem cells in Hydra: multipotency and decision-making
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DOI：
10.1387/ijdb.113476cd
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发表时间：
2012-01-01
影响因子：
0.7
通讯作者：
David, Charles N.
中科院分区：
文献类型：
--
作者：
David, Charles N.
水螅中的间质干细胞构成了一群多能细胞，在水螅息肉的生长和出芽过程中不断产生分化产物。它们还在经历性分化的动物中产生生殖细胞。克隆实验表明，间质干细胞是多能的。干细胞谱系的体内追踪已经揭示干细胞对称分裂以产生两个干细胞或不对称分裂以产生一个干细胞子细胞和一个引发神经或神经胶质细胞分化的子细胞。在定型后，一些神经细胞前体从体柱迁移到头部或足部区域，从而引起在这些区域中观察到的高密度神经细胞。干细胞增殖受自我更新概率的变化调节，并受干细胞密度控制。神经细胞的定型是由包括头部激活剂在内的几种肽控制的。影响巨噬细胞定型的因素尚不清楚，但wnt和notch信号都是定型前体分化所必需的。
Interstitial stem cells in Hydra constitute a population of multipotent cells, which continuously give rise to differentiated products during the growth and budding of Hydra polyps. They also give rise to germ cells in animals undergoing sexual differentiation. Cloning experiments have shown that interstitial stem cells are multipotent. In vivo tracing of stem cell lineages has revealed that stem cells divide symmetrically to yield two stem cells or asymmetrically to yield one stem cell daughter and one daughter cell which initiates nerve or nematocyte differentiation. Following commitment, some nerve cell precursors migrate from the body column into the head or foot region, thus giving rise to the high density of nerve cells observed in these regions. Stem cell proliferation is regulated by changes in the self-renewal probability and is controlled by stem cell density. Nerve cell commitment is controlled by several peptides including the Head Activator. Factors affecting nematocyte commitment are not known, but wnt and notch signaling are both required for differentiation of committed precursors.