Source of electrocardiographic ST changes in subendocardial ischemia
Source of electrocardiographic ST changes in subendocardial ischemia
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DOI：
10.1161/01.res.82.9.957
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发表时间：
1998-05-18
影响因子：
20.1
通讯作者：
Kilpatrick, D
中科院分区：
文献类型：
--
作者：
Li, DS;Li, CY;Kilpatrick, D
为了弄清与缺血相关的心电图ST段压低的来源，建立了一种绵羊心内膜下缺血模型，在该模型中，同时标测了心外膜和心内膜ST段的电位，并利用Biomain技术建立了一个计算机模型来解释结果，在同一动物中，左前降支和左回旋支依次部分收缩，造成心肌不同区域的缺血。本文报道了36只绵羊的试验结果和计算机模拟结果。两种缺血源的心外膜电位分布非常相似(r=0.77+/-0.14，P
To clarify the source of electrocardiographic ST depression associated with ischemia, a sheep model of subendocardial ischemia was developed in which simultaneous epicardial and endocardial ST potentials were mapped, and a computer model using the bidomain technique was developed to explain the results, To produce ischemia in different territories of the myocardium in the same animal, the left anterior descending coronary artery and left circumflex coronary artery were partially constricted in sequence. Results from 36 sheep and the computer simulation are reported. The distributions of epicardial potentials from either ischemic source were very similar (r=0.77+/-0.14, P