Therapeutic insights from genomic studies of head and neck squamous cell carcinomas.
Therapeutic insights from genomic studies of head and neck squamous cell carcinomas.
复制标题
从头颈鳞状细胞癌的基因组研究中获得的治疗见解。
DOI：
10.1158/2159-8290.cd-14-1205
复制
发表时间：
2015-03
期刊：
影响因子：
28.2
通讯作者：
Grandis JR
中科院分区：
文献类型：
--
作者：
Hammerman PS;Hayes DN;Grandis JR
头颈部鳞状细胞癌的大规模和全面的基因组调查现在大大增加了我们对这种疾病的多样性和驱动这些肿瘤的关键基因组变化的理解。这些研究的结果开始为头颈部鳞状细胞癌患者引入新的治疗方法提供信息。在这里，我们回顾了最近头颈癌基因组研究的一些关键发现，包括癌症基因组图谱网络迄今为止最全面的研究。
Large and comprehensive genomic surveys of head and neck squamous cell carcinomas are now greatly increasing our understanding of the diversity of this disease and the key genomic changes, which drive these tumors. The results from these studies are beginning to inform the introduction of novel therapies for patients with head and neck squamous cell cancers. Here, we review some of the key findings from recent genomic studies of head and neck cancers including the most comprehensive study to date from The Cancer Genome Atlas Network.