Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder
Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder
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DOI：
10.1016/j.neulet.2008.08.080
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发表时间：
2008-11-14
影响因子：
2.5
通讯作者：
Chen, Li-Fen
中科院分区：
文献类型：
--
作者：
Chen, Shyan-Shiou;Tu, Pei-Chi;Chen, Li-Fen
最近的功能成像研究表明，大脑在测试状态下表现出连贯的，同步的活动，并且在各种精神疾病中可能会受损。为了探讨双相情感障碍患者的神经动力学变化，我们采用一种新的非线性测量方法“相似性指数”对脑磁图（MEG）记录进行分析，检验双相情感障碍患者额叶皮层不同频段内存在同步性变化的假设。10例双相I障碍患者和10名正常对照者在正常情绪期进行了2 min闭眼静息记录。选取11个通道的脑磁图数据进行分析。计算每个受试者的δ（2-4 Hz）、θ（4-8 Hz）、α（8-12 Hz）和β（12- 2 - 4 Hz）频段的同步水平，并进行组间比较。结果表明，双相情感障碍患者的显著动态变化可表现为慢频率振荡同步性增加（δ）和快频率振荡同步性降低（β）。此外，双相情感障碍患者的β同步化水平与Wisconsin卡片分类任务中的保留错误呈正相关，提示双相情感障碍患者存在执行功能缺陷。我们的研究结果表明，用非线性动力学方法分析静息状态下自发脑磁图记录可能揭示BD神经动力学的细微区域变化。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
Recent functional imaging studies demonstrated that brain exhibit coherent, synchronized activities during testing state and the dynamics may be impaired in various psychiatric illnesses. In order to investigate the change of neural dynamics in bipolar disorder, we used a new nonlinear measurement "similarity index" to analyze the magnetoencephalography (MEG) recordings and test the hypothesis that there are synchronization changes within different frequency bands in the frontal cortex of patients with bipolar disorder. Ten patients with bipolar I disorder during euthymic phase and ten normal controls underwent 2 min eye-closed resting recording with a whole-head 306-channel MEG system. Eleven channels of MEG data from frontal area were selected for analysis. Synchronization level in the delta (2-4 Hz), theta (4-8 Hz), alpha (8-12 Hz) and beta (12-24 Hz) bands was calculated for each subject and compared across group. The results showed that significant dynamic changes in bipolar patients can be characterized by increased synchronization of slow frequency oscillations (delta) and decreased synchronization of fast frequency oscillations (beta). Furthermore, the positive correlation between beta synchronization level and preservative errors in Wisconcin Card sorting task was found which would implicate the deficit of executive function in bipolar patients. Out findings indicate that analysis of spontaneous MEG recordings at resting state using nonlinear dynamic approaches may disclose the Subtle regional changes of neural dynamics in BD. (c) 2008 Elsevier Ireland Ltd. All rights reserved.