Withdrawal from continuous cocaine administration: time dependent changes in accumbens 5-HT3 receptor function and behavioral tolerance.
Withdrawal from continuous cocaine administration: time dependent changes in accumbens 5-HT3 receptor function and behavioral tolerance.
复制标题
连续使用可卡因戒断：伏隔核 5-HT3 受体功能和行为耐受性的时间依赖性变化。
DOI：
10.1007/s002130050899
复制
发表时间：
1999
影响因子：
3.4
通讯作者：
EllinwoodJr,EH
中科院分区：
文献类型：
--
作者：
King,GR;Xiong,Z;EllinwoodJr,EH
We have previously reported that continuous cocaine administration functionally down regulates 5-HT3receptors in the nucleus accumbens. The current experiments evaluated the duration of behavioral tolerance to cocaine and whether the duration of behavioral tolerance and 5-HT3receptor down-regulation co-varied. Rats were withdrawn from a pretreatment regimen (40 mg/kg/per day cocaine or 0.9% saline for 14 days) for 1, 7 or 14 days. The rats were either sacrificed, and slices from the nucleus accumbens obtained, or were exposed to behavioral rating procedures. The results indicated that continuous cocaine administration significantly attenuated the ability of mCPBG to facilitate K+-stimulated DA release on days 1 and 7, but not day 14, of withdrawal. Furthermore, continuous cocaine administration induced behavioral tolerance to a cocaine challenge on days 1 and 7, but not day 14, of withdrawal. These results suggest that continuous cocaine administration functionally down-regulates 5-HT3receptors in the nucleus accumbens, and this functional down-regulation co-varies with the behavioral tolerance induced by continuous cocaine administration. Hence, a functional down-regulation of accumbens 5-HT3receptors may represent a partial mechanism for the tolerance following continuous cocaine administration.
