The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle.

The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle.
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DOI:
10.3390/v13020324
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发表时间:
2021-02-20
期刊:
Viruses
影响因子:
--
通讯作者:
Lever AML
Lever AML
中科院分区:
其他
文献类型:
--
作者:
Meng B;Lever AML

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病毒是依赖宿主细胞因子复制和传播的专性寄生虫。内体转运所需的分选复合物(ESCRT)系统与表面蛋白的分选和降解有关,是被不同家族的病毒劫持的宿主机制之一。从对ESCRT和病毒的研究中获得的知识反过来又极大地促进了我们对ESCRT途径所涉及的许多其他细胞功能的理解,例如,胞质分裂这篇综述强调了ESCRT途径和包膜病毒的病毒因子之间的相互作用,特别强调逆转录病毒。
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the host machineries hijacked by viruses across diverse families. Knowledge gained from research into ESCRT and viruses has, in turn, greatly advanced our understanding of many other cellular functions in which the ESCRT pathway is involved, e.g., cytokinesis. This review highlights the interplay between the ESCRT pathway and the viral factors of enveloped viruses with a special emphasis on retroviruses.
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