Risk-reducing effect of education in Alzheimer's disease
Risk-reducing effect of education in Alzheimer's disease
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DOI：
10.1002/gps.2043
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发表时间：
2008-11-01
影响因子：
4
通讯作者：
Aasly, Jan
中科院分区：
文献类型：
--
作者：
Sando, Sigrid Botne;Melquist, Stacey;Aasly, Jan
目的探讨教育对老年痴呆症（AD）发病风险的影响。方法采用病例对照研究（2003-2006），选取373例AD患者和559例无一级亲属已知痴呆的健康对照者。对所有个体进行APOE等位基因分型。以APOE epsilon 4等位基因数量和受教育程度为协变量，采用二元logistic回归计算AD发生的比值比（OR）。对男性和女性以及不同年龄组分别进行了分析。结果携带1个APOE F，4等位基因的人发生AD的OR值为4.2，携带2个APOE ε 4等位基因的人发生AD的OR值为12.4。当调整APOE 0等位基因的数量时，8-9年受教育程度的受试者与6-7年受教育程度的受试者相比，患AD的OR显著降低，10-18年受教育程度的受试者的OR进一步降低。这些发现适用于所有被研究的年龄组，包括男性和女性。结论：教育对男性和女性以及所有年龄组的临床AD发病风险均具有剂量依赖性的保护作用，在调整APOE epsilon 4等位基因数量时也是如此。男性具有保护作用，可能至少部分是因为他们的教育水平更高。版权所有(C) 2008约翰威利父子有限公司
Objective To estimate the effect of education on the risk of Alzheimer's disease (AD).Methods 373 patients diagnosed with AD and 559 healthy control individuals without first degree relatives with known dementia, were included in a case-control study (2003-2006). All individuals were genotyped for APOE alleles. Odds ratio (OR) for developing AD was calculated by binary logistic regression, with the number of APOE epsilon 4 alleles and educational level as covariates. Analyses were carried out separately for men and women and for different age groups.Results Carriers of one APOE F,4 allele had OR of 4.2, and carriers of two APOE epsilon 4 alleles OR of 12.4 for developing AD. When adjusted for the number of APOE 0 alleles, OR for developing AD was significantly reduced in participants with 8-9 years of education compared to those with only 6-7 years, and was reduced further for those with 10-18 years of education. These findings were obtained for all the age groups studied and for both men and women.Conclusions Education had a consistently protective effect on the risk of developing clinical AD in a dose-dependent manner in both men and women, and in all age groups, also when adjusting for the number of APOE epsilon 4 alleles. Male gender was protective, probably at least in part because of a higher educational level. Copyright (C) 2008 John Wiley & Sons, Ltd.