High RIPK3 expression is associated with a higher risk of early kidney transplant failure.
High RIPK3 expression is associated with a higher risk of early kidney transplant failure.
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DOI：
10.1016/j.isci.2023.107879
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发表时间：
2023-10-20
期刊：
影响因子：
5.8
通讯作者：
Kemmner, Stephan
中科院分区：
文献类型：
--
作者：
Wahida, Adam;Schmaderer, Christoph;Buettner-Herold, Maike;Branca, Caterina;Donakonda, Sainitin;Haberfellner, Flora;Torrez, Carlos;Schmitz, Jessica;Schulze, Tobias;Seibt, Tobias;Oellinger, Rupert;Engleitner, Thomas;Haller, Bernhard;Steiger, Katja;Guenthner, Roman;Lorenz, Georg;Yabal, Monica;Bachmann, Quirin;Braunisch, Matthias C.;Moog, Philipp;Matevossian, Edouard;Assfalg, Volker;Thorban, Stefan;Renders, Lutz;Spath, Martin R.;Mueller, Roman-Ulrich;Stippel, Dirk L.;Weichert, Wilko;Slotta-Huspenina, Julia;von Vietinghoff, Sibylle;Viklicky, Ondrej;Green, Douglas R.;Rad, Roland;Amann, Kerstin;Linkermann, Andreas;Brasen, Jan Hinrich;Heemann, Uwe;Kemmner, Stephan
肾缺血再灌注损伤(IRI)与同种异体移植物存活率降低有关，冷缺血时间每增加一小时，肾移植后移植物衰竭和死亡率的风险增加。受体相互作用蛋白激酶3(RIPK3)是坏死性下垂的关键效应因子，是细胞死亡的一种调节形式。在这里，我们评估了肾移植中IRI后的第一个人类RIPK3表达数据集。初步分析包括374例同种异体肾移植患者在再灌注10分钟后获得的基线活检样本。RIPK3主要表达于受IRI影响的近端肾小管细胞和远端肾小管细胞。事件发生时间分析显示，在多变量分析中，RIPK3的高表达与一年内移植失败的风险和一年(死亡审查)移植失败的预后显著相关，与供者和受者相关的危险因素无关。RIPK3评分还与供者死亡、冷缺血时间和肾小管损伤程度相关。首次在人类中比较肾活检组织中RIPK3表达与临床结果的研究RIPK3表达与冷缺血时间相关RIPK3表达与1年移植失败的高风险相关RIPK3表达预测1年移植失败独立于受体风险因素肾病；分子生物学
Renal ischemia-reperfusion injury (IRI) is associated with reduced allograft survival, and each additional hour of cold ischemia time increases the risk of graft failure and mortality following renal transplantation. Receptor-interacting protein kinase 3 (RIPK3) is a key effector of necroptosis, a regulated form of cell death. Here, we evaluate the first-in-human RIPK3 expression dataset following IRI in kidney transplantation. The primary analysis included 374 baseline biopsy samples obtained from renal allografts 10 minutes after onset of reperfusion. RIPK3 was primarily detected in proximal tubular cells and distal tubular cells, both of which are affected by IRI. Time-to-event analysis revealed that high RIPK3 expression is associated with a significantly higher risk of one-year transplant failure and prognostic for one-year (death-censored) transplant failure independent of donor and recipient associated risk factors in multivariable analyses. The RIPK3 score also correlated with deceased donation, cold ischemia time and the extent of tubular injury. First-in-human study comparing RIPK3 expression in renal biopsies with clinical outcome RIPK3 expression correlates with cold ischemia time RIPK3 expression is associated with a higher risk of 1-year transplant failure RIPK3 expression predicts 1-year graft failure independent of recipient risk factors Nephrology; Molecular biology
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影响因子：
6.2
作者：
Hall IE;Reese PP;Doshi MD;Weng FL;Schröppel B;Asch WS;Ficek J;Thiessen-Philbrook H;Parikh CR
通讯作者：
Parikh CR
影响因子：
8.8
作者：
Sellares, J.;de Freitas, D. G.;Halloran, P. F.
通讯作者：
Halloran, P. F.
影响因子：
19.6
作者：
Coemans, Maarten;Suesal, Caner;Naesens, Maarten
通讯作者：
Naesens, Maarten
影响因子：
8.8
作者：
Hart, A.;Lentine, K. L.;Snyder, J. J.
通讯作者：
Snyder, J. J.
影响因子：
64.5
作者：
Micheau, O;Tschopp, J
通讯作者：
Tschopp, J