IL-6 levels decrease with SSRI treatment in patients with major depression
IL-6 levels decrease with SSRI treatment in patients with major depression
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DOI：
10.1002/hup.717
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发表时间：
2005-10-01
影响因子：
1.7
通讯作者：
Göka, E
中科院分区：
文献类型：
--
作者：
Basterzi, AD;Aydemir, Ç;Göka, E
目的 一些证据表明，促炎细胞因子产生增加的免疫反应常常伴随重度抑郁症。本研究的目的是检测重度抑郁症患者的血清IL-6水平以及选择性5-羟色胺再摄取抑制剂（SSRI）治疗期间IL-6水平的变化。 方法 本研究纳入了23名经DSM-IV诊断为重度抑郁症的患者和23名健康匹配的对照者。抑郁症的严重程度是用汉密尔顿抑郁量表来衡量的。在基线和治疗第 6 周获取 IL-6 水平的血液样本，并使用固相夹心酶免疫测定法评估 IL-6 浓度。所有患者均接受 SSRL 结果 在基线时，患者和对照组之间的 IL-6 水平没有显示出统计学上的显着差异。然而，SSRIs治疗后，患者和对照组的IL-6水平均显着低于基线IL-6水平。结论本研究结果表明，促炎细胞因子在重性抑郁症的治疗过程中表现出一些变化。这些发现也可能被认为支持抗抑郁药对免疫系统具有调节作用的假设。版权所有 (c) 2005 John Wiley & Sons, Ltd.
Objective Some evidence indicates that an immune response with an increased production of proinflammatory cytokines often accompanies major depression. The objective of this study was to examine the serum levels of IL-6 in patients with major depression and the changes occurring in IL-6 levels during treatment with selective serotonin reuptake inhibitors (SSRI).Method Twenty-three patients with a DSM-IV diagnosis of major depressive disorder and 23 healthy matched controls were included in the study. The severity of depression was measured with the Hamilton rating scale for depression. Blood samples for IL-6 levels were obtained at baseline and at week 6 of treatment and IL-6 concentrations were evaluated using a solid phase sandwich enzyme immunoassay. All patients were treated with an SSRLResults The IL-6 levels showed no statistically significant difference between the patients and the controls at baseline. However, IL-6 levels after treatment with SSRIs were significantly lower compared with the baseline IL-6 levels of both the patients and the controls.Conclusion The results of this study suggest that proinflammatory cytokines show some changes during the course of treatment of major depression. These findings might also be considered as supporting the hypothesis of a modulatory role of antidepressants on the immune system. Copyright (c) 2005 John Wiley & Sons, Ltd.