Photocontrol of spatial orientation and DNA cleavage activity of copper(II)-bound dipeptides linked by an azobenzene derivative.
Photocontrol of spatial orientation and DNA cleavage activity of copper(II)-bound dipeptides linked by an azobenzene derivative.
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DOI：
10.1021/ic8007443
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发表时间：
2008-05
影响因子：
4.6
通讯作者：
H. Prakash;A. Shodai;H. Yasui;H. Sakurai;S. Hirota
中科院分区：
文献类型：
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作者：
H. Prakash;A. Shodai;H. Yasui;H. Sakurai;S. Hirota
偶氮苯衍生物连接的铜(II)离子结合的CysGly二肽在反式和顺式之间发生了光异构化。两个铜(II)离子中心在顺式中彼此靠近，而在反式中彼此远离。顺式铜络合物具有DNA切割活性，而反式铜络合物的DNA裂解活性很小。顺式DNA的切割活性归因于紧密定位的铜(II)中心的协同作用。结果表明，金属离子的协同作用对DNA的切割具有光控作用。
Copper(II) ion-bound CysGly dipeptides linked by an azobenzene derivative were photoisomerized between the trans and cis forms. The two copper(II) ion centers were positioned close to each other in the cis form, whereas they were far away from each other in the trans form. The copper complex in the cis form exhibited DNA cleavage activity, whereas the activity in the trans form was negligible. The DNA cleavage activity of the cis form is attributed to the cooperation of the closely located copper(II) centers. The present results show the photocontrol of the cooperation of metal ions for DNA cleavage.