Sex differences in analgesic responses: evidence from experimental pain models
Sex differences in analgesic responses: evidence from experimental pain models
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DOI：
10.1097/00003643-200219261-00004
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发表时间：
2002-01-01
影响因子：
3.6
通讯作者：
Fillingim, RB
中科院分区：
文献类型：
--
作者：
Fillingim, RB
背景和目的：性别对疼痛体验的影响已经受到了相当多的实证关注。女性在几种形式的临床疼痛的风险更大，并表现出更大的知觉反应实验疼痛。近年来，研究者将注意力转向与性别有关的因素对镇痛反应的影响。本综述的目的是研究文献中的性别差异镇痛responses，强调从实验study.Methods的结果：首先，在实验室疼痛研究的重要方法问题，和性别差异的反应实验引起的疼痛简要说明。接下来，以前的数据从非人类动物研究和人类实验和临床研究有关的性别差异镇痛进行了讨论。此外，初步结果是从一个正在进行的研究在我们的实验室检查镇痛反应的妇女和男子。结果和结论：无论是以前的研究和我们的实验室的初步研究结果表明，阿片类药物产生更大的镇痛反应的妇女比男性。潜在的机制性别差异镇痛提出了建议，并为今后的研究提出了重要的方向。
Background and objective: Sex-related influences on the experience of pain have received considerable empirical attention. Women are at greater risk for several forms of clinical pain and exhibit greater perceptual responses to experimental pain. In recent years, investigators have turned their attention to the influence of sex-related factors on analgesic responses. The purpose of this review is to examine the literature on sex differences in analgesic responses, emphasizing findings from experimental studies.Methods: First, important methodological issues in laboratory pain research are presented, and sex differences in responses to experimentally-induced pain are briefly addressed. Next, previous data from non-human animal research and human experimental and clinical research related to sex differences in analgesia are discussed. Also, preliminary results are presented from an ongoing study in our laboratory examining analgesic responses in women and men.Results and conclusions: Both previous research and preliminary findings from our laboratory suggests that opioids produce greater analgesic responses in women than men. Potential mechanisms underlying sex differences in analgesia are proposed, and important directions for future research are suggested.