Experimental study on the metabolism of triethylamine in man.
Experimental study on the metabolism of triethylamine in man.
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DOI：
10.1136/oem.45.4.262
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发表时间：
1988-04
期刊：
影响因子：
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通讯作者：
B. Akesson;S. Skerfving;L. Mattiasson
中科院分区：
文献类型：
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作者：
B. Akesson;S. Skerfving;L. Mattiasson
五名健康志愿者通过吸入暴露于三乙胺（TEA;约10、20、35和50 mg/m3，4或8小时），三乙胺是一种广泛用作聚氨酯系统固化剂的化合物。血浆和尿液分析显示，平均24%的TEA被生物转化为三乙胺-N-氧化物（TEAO），但个体间差异很大（15 - 36%）。TEA和TEAO在尿液中定量消除。TEA和TEAO的血浆和尿液浓度在暴露结束后迅速下降（TEA的平均半衰期为3.2h）。空气中的TEA水平与暴露结束后两小时内获得的样本中的尿液浓度之间存在良好的相关性。因此，在此期间服用的尿中TEA水平可用作暴露的生物监测。10 mg/m3的空气浓度对应于约40 mmol/mol肌酸酐的平均尿浓度（在久坐工作时）。
Five healthy volunteers were exposed by inhalation to triethylamine (TEA; four or eight hours at about 10, 20, 35, and 50 mg/m3), a compound widely used as a curing agent in polyurethane systems. Analysis of plasma and urine showed that an average of 24% of the TEA was biotransformed into triethylamine-N-oxide (TEAO) but with a wide interindividual variation (15-36%). The TEA and TEAO were quantitatively eliminated in the urine. The plasma and urinary concentrations of TEA and TEAO decreased rapidly after the end of exposure (average half time of TEA was 3.2 h). There was an excellent association between air levels of TEA and the urinary concentrations in samples obtained within two hours of the end of exposure. Thus the urinary level of TEA taken in this period is useful as a biological monitoring of exposure. An air concentration of 10 mg/m3 corresponds to an average urinary concentration of about 40 mmol/mol creatinine (at sedentary work).