Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries
Platelet-Rich Plasma Therapy in the Treatment of Diseases Associated with Orthopedic Injuries
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DOI：
10.1089/ten.teb.2019.0292
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发表时间：
2020-11-03
影响因子：
6.4
通讯作者：
Wang, Yu
中科院分区：
文献类型：
--
作者：
Fang, Jie;Wang, Xin;Wang, Yu
富血小板血浆 (PRP) 是一种由全血制备的自体血小板浓缩物，被激活后可释放生长因子 (GF) 和细胞因子，并已被证明具有减少炎症和改善组织合成代谢以促进再生的潜在能力。 PRP 的使用因其丰富的 GF 和细胞因子而提供了修复潜力，而这些是启动和调节软组织和硬组织再生微环境的关键。在门诊患者中，骨科损伤很常见，包括骨缺损、韧带损伤、附着点病变、肌肉骨骼损伤、周围神经损伤、慢性不愈伤口、关节软骨病变和骨关节炎，这些损伤是由外伤、运动相关或其他类型的创伤或肿瘤切除引起的。通常需要手术干预来治疗这些损伤。然而，由于缺损区域再生能力有限、血供不足等多种原因，这些治疗通常效果不理想，且后续治疗具有挑战性。本综述的目的是探讨PRP治疗骨科损伤相关疾病领域的未来研究。影响陈述近年来，富血小板血浆（PRP）已广泛应用于骨科损伤相关疾病的治疗，众多研究结果令人鼓舞。由于骨科损伤相关疾病在临床上较为常见，作为一种保守治疗方法，越来越多的医生和患者接受PRP。重要的是，PRP是一种自体血液的生物制品，通过离心过程从全血中富集血小板而获得，并发症很少，例如自体来源的免疫原性可以忽略不计，而且在无菌环境下通过高效且经济的方法生产也很简单。然而，PRP治疗的适用性、优点和缺点尚未完全阐明。本文旨在探讨PRP治疗骨科损伤相关疾病领域的未来研究，并为临床提供参考。
Platelet-rich plasma (PRP) is an autologous platelet concentrate prepared from the whole blood that is activated to release growth factors (GFs) and cytokines and has been shown to have the potential capacity to reduce inflammation and improve tissue anabolism for regeneration. The use of PRP provides a potential for repair due to its abundant GFs and cytokines, which are key in initiating and modulating regenerative microenvironments for soft and hard tissues. Among outpatients, orthopedic injuries are common and include bone defects, ligament injury, enthesopathy, musculoskeletal injury, peripheral nerve injury, chronic nonhealing wounds, articular cartilage lesions, and osteoarthritis, which are caused by trauma, sport-related or other types of trauma, or tumor resection. Surgical intervention is often required to treat these injuries. However, for numerous reasons regarding limited regeneration capacity and insufficient blood supply of the defect region, these treatments commonly result in unsatisfactory outcomes, and follow-up treatment is challenging. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries.Impact statementIn recent years, platelet-rich plasma (PRP) has become widely used in the treatment of diseases associated with orthopedic injuries, and the results of numerous studies are encouraging. Due to diseases associated with orthopedic injuries being common in clinics, as a conservative treatment, more and more doctors and patients are more likely to accept PRP. Importantly, PRP is a biological product of autologous blood that is obtained by a centrifugation procedure to enrich platelets from whole blood, resulting in few complications, such as negligible immunogenicity from an autologous source, and it is also simple to produce through an efficient and cost-effective method in a sterile environment. However, the applicability, advantages, and disadvantages of PRP therapy have not yet been fully elucidated. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries, as well as to provide references for clinics.