Base-promoted one-pot tandem reaction of 3-(1-alkynyl)chromones under microwave irradiation to functionalized amino-substituted xanthones.
Base-promoted one-pot tandem reaction of 3-(1-alkynyl)chromones under microwave irradiation to functionalized amino-substituted xanthones.
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DOI：
10.1021/jo1013614
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发表时间：
2010-09
期刊：
影响因子：
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通讯作者：
Yang Liu;Liping Huang;Fuchun Xie;Youhong Hu
中科院分区：
文献类型：
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作者：
Yang Liu;Liping Huang;Fuchun Xie;Youhong Hu
在微波辐射下，以3-（1-炔基）色酮和乙腈为原料，通过碱促进的一锅串联反应合成了氨基取代的口山酮3。该串联方法涉及多个反应，例如迈克尔加成/环化/1，2-加成，而不使用过渡金属催化剂。该方法为快速构建类似天然产物的多种氨基取代咕吨酮支架提供了一种有效途径。
A base-promoted one-pot tandem reaction has been developed from 3-(1-alkynyl)chromones with various acetonitriles to afford functionalized amino-substituted xanthones 3 under microwave irradiation. This tandem process involves multiple reactions, such as Michael addition/cyclization/1,2-addition, without a transition metal catalyst. This method provides an efficient approach to build up natural product-like diversified amino-substituted xanthone scaffolds rapidly.