Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials.
Clinically Meaningful Change in Sexual Desire in the Psychosexual Daily Questionnaire in Older Men from the TTrials.
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T 试验中老年男性性心理每日问卷调查中性欲的临床意义变化。
DOI：
10.1016/j.jsxm.2019.04.003
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Swerdloff,RonaldS
中科院分区：
文献类型：
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作者：
Stephens-Shields,AlisaJ;Wang,Christina;Preston,Peter;Snyder,PeterJ;Swerdloff,RonaldS
背景最近一项针对参与睾酮试验 (TTrials) 的老年男性的研究定义了年龄≥65 岁性腺功能减退男性的性心理每日问卷 (PDQ) 问题 4 中具有临床意义的变化。本研究定义了通过 PDQ 问题 1 评估的同一人群中性欲的临床有意义的变化。目的是确定性腺功能减退的老年男性 PDQ 问题 1 的答案是否有临床意义的变化。方法 TTrials 性功能试验的参与者被随机分为训练组和测试组。基于锚定的方法，包括回归分析、受试者工作特征曲线和经验累积分布函数，用于确定训练集中问题 1 的临床有意义的变化，并在测试集中评估选定的阈值以评估睾酮治疗的效果。结果 PDQ 问题 1 的临床有意义的增加确定为 ≥0.7 分。临床意义 PDQ 的问题 1 可用于评估性行为 睾酮治疗对性欲的反应。优点和局限性数据是从一项针对老年性腺功能减退男性的大型研究中获得的。结论具有临床意义的性欲改善是 PDQ 问题 1 得分变化≥0.7。
BackgroundA recent study of older men participating in the Testosterone Trials (TTrials) defined a clinically meaningful change in the Psychosexual Daily Questionnaire (PDQ) question 4 in hypogonadal men age ≥65 years. This study defines clinically meaningful change in the same population for sexual desire assessed by PDQ question 1.AimTo determine a clinically meaningful change in the answers to question 1 of the PDQ in hypogonadal older men.MethodsParticipants in the Sexual Function Trial of the TTrials were randomly divided into a training and test set. Anchor-based methods, including regression analysis, receiver operating characteristic curves, and empirical cumulative distribution functions, were used to determine a clinically meaningful change on question 1 in the training set, and the selected threshold was evaluated in the test set for an effect of testosterone treatment.ResultsA clinically meaningful increase in question 1 of the PDQ was determined to be ≥0.7 points.Clinical ImplicationsQuestion 1 of the PDQ can be used to assess sexual desire in response to testosterone treatment.Strengths & LimitationsData were obtained from a single large study of older hypogonadal men.ConclusionClinically meaningful improvement of sexual desire is a change of ≥0.7 in the score of question 1 of the PDQ.