Prevalence and risk factors for loss of bone mineral density in male Japanese patients with HIV
Prevalence and risk factors for loss of bone mineral density in male Japanese patients with HIV
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日本男性艾滋病毒感染者骨密度下降的患病率和危险因素
DOI：
10.1097/qai.0b013e3182718d4c
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Ota Y
中科院分区：
文献类型：
--
作者：
Koga I;Yoshino Y;Kitazawa T;Kurahashi I;Ota Y
致编辑：随着联合抗逆转录病毒治疗 (cART) 降低了 HIV 感染者的死亡率，机会性感染被包括骨矿物质密度 (BMD) 损失在内的长期并发症所取代。 1-9 它于 1999 年首次报道，并在过去十年中出现10、11，可能使 HIV 感染者骨折的风险更高。 12, 13 原因被认为是多因素的，包括 HIV 感染本身、体重指数 (BMI)、估计肾小球滤过率 (eGFR)、睾酮水平和肝炎合并感染。 14-17 一些文章将使用蛋白酶抑制剂和替诺福韦 (TDF) 与较低的 BMD 联系起来。 18-20 大多数与 HIV 感染者 BMD 损失相关的文章均来自北美、欧洲和大洋洲。因此，针对感染艾滋病毒的亚洲人的 BMD 研究代表性不足。在这项工作中，我们以日本男性 HIV 感染者为对象，研究了他们中 BMD 损失的患病率和严重程度，并试图确定与 BMD 损失相关的临床因素。本研究纳入了 40 名年龄在 21 至 70 岁之间、就诊于帝京大学医院的日本男性 HIV 感染者。本研究得到了帝京大学医学院伦理委员会的批准，并且患者签署了书面知情同意书。这些患者从 2010 年 3 月至 2012 年 2 月接受了相同的双重 BMD 分析。
To the Editors: As the mortality of HIV-infected individuals was improved by combination antiretroviral therapy (cART), opportunistic infections were replaced by long-term complications including loss of bone mineral density (BMD). 1-9 It was first reported in 1999 and has emerged in the last decade10, 11 and has probably placed HIV-infected individuals at higher risk of bone fractures. 12, 13 The causes are considered to be multifactorial and include HIV infection itself, body mass index (BMI), estimated glomerular filtration rate (eGFR), testosterone level, and hepatitis coinfection. 14-17 Some articles link the use of protease inhibitors and the tenofovir (TDF) with lower BMD. 18-20 Most of the articles associated with BMD loss in HIV-infected patients have been reported from North America, Europe, and Oceania. Accordingly, the BMD research on HIV-infected Asians is underrepresented. In this work, we focused on male Japanese HIV-infected patients and studied the prevalence and severity of BMD loss among them and attempted to determine clinical factors related to BMD loss.Forty male Japanese HIV-infected individuals aged from 21 to 70 years who visited the Teikyo University Hospital were enrolled in this study. This study was approved by the ethical committee of the Teikyo University School of Medicine, and the patients gave written informed consent. The patients underwent BMD analyses from March 2010 to February 2012 with the same dual