Neural activity in the frontal eye fields modulated by the number of alternatives in target choice
Neural activity in the frontal eye fields modulated by the number of alternatives in target choice
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DOI：
10.1523/jneurosci.3596-07.2008
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发表时间：
2008-02-27
影响因子：
5.3
通讯作者：
Keller, Edward L.
中科院分区：
文献类型：
--
作者：
Lee, Kyoung-Min;Keller, Edward L.
选择相同的反应可能不使用相同的神经机制时，选择的替代品（NA）的数量变化，如希克定律所建议的。为了阐明选择机制，在颜色-位置选择眼跳任务中，当潜在目标的数量变化时，对额叶眼野（FEF）神经元进行了监测。视觉反应的替代目标下降NA增加，而近距离活动增加NA。这些调制的FEF活动似乎密切相关的选择过程，因为活动的增强与目标选择的时间相吻合，神经调制更大的NA增加，功能预期的神经相关的选择过程中，从希克定律的角度。我们目前的观察提出了两个以前没有报道过的FEF神经元行为的新概念：（1）在延迟眼跳范式中，被称为“阶段性视觉”的细胞在眼跳时的选择反应任务中表现出这种活动，这些细胞在眼跳时的周跳间隔中不放电;以及（2）FEF视皮层细胞的活动在扫视周围活动和扫视触发时间之间显示出反比关系，活动水平越高，扫视反应时间这些研究结果支持该地区的参与，通过共激活和竞争性的相互作用的神经群体，代码的替代行动集的目标选择的感觉运动翻译。
Selection of identical responses may not use the same neural mechanisms when the number of alternatives ( NA) for the selection changes, as suggested by Hick's law. For elucidating the choice mechanisms, frontal eye field ( FEF) neurons were monitored during a color-to-location choice saccade task as the number of potential targets was varied. Visual responses to alternative targets decreased as NA increased, whereas perisaccade activities increased with NA. These modulations of FEF activities seem closely related to the choice process because the activity enhancements coincided with the timing of target selection, and the neural modulation was greater as NA increased, features expected of neural correlates for a choice process from the perspective of Hick's law. Our current observations suggest two novel notions of FEF neuronal behavior that have not been reported previously: ( 1) cells called "phasic visual" that do not discharge in the perisaccade interval in a delayed-saccade paradigm show such activity in a choice response task at the time of the saccade; and ( 2) the activity in FEF visuomotor cells display an inverse relationship between perisaccadic activity and the time of saccade triggering with higher levels of activity leading to longer saccade reaction times. These findings support the area's involvement in sensory-motor translation for target selection through coactivation and competitive interaction of neural populations that code for alternative action sets.