Pancreas Transplantation From Donors After Circulatory Death From the United Kingdom
Pancreas Transplantation From Donors After Circulatory Death From the United Kingdom
复制标题
DOI：
10.1111/j.1600-6143.2012.04075.x
复制
发表时间：
2012-08-01
影响因子：
8.8
通讯作者：
Friend, P. J.
中科院分区：
文献类型：
--
作者：
Muthusamy, A. S. R.;Mumford, L.;Friend, P. J.
这项研究报告了循环死亡(DCD)后供者胰腺移植(Maastraht III&IV)和脑干已故供者胰腺移植(DBD)的短期比较结果。2006年1月至2010年12月期间，英国共进行了1009例胰腺移植手术，其中134例来自DCD，875例来自DBD。DCD移植物没有进行死前药物干预。DCD组和DBD组的一年胰腺和患者存活率相似，如果作为SPK手术，DCD组的胰腺移植物存活率显著高于DCD组。血栓形成导致的早期移植物丢失(8%比4%)是DCD队列中早期移植物丢失的主要原因。这些来自年龄、体重指数、死前干预等更广泛接受标准的供者的结果表明，DCD胰腺移植可能比以前认识到的更大的应用潜力。
This study reports the comparative short-term results of pancreas transplantation from donors after circulatory death (DCD) (Maastricht III & IV), and pancreases from brainstem deceased donors (DBD). Between January 2006 and December 2010, 1009 pancreas transplants were performed in the United Kingdom, with 134 grafts from DCD and 875 from DBD. DCD grafts had no premortem pharmacological interventions performed. One-year pancreas and patient survival was similar between DCD and DBD, with pancreas graft survival significantly better in the DCD cohort if performed as an SPK. Early graft loss due to thrombosis (8% vs. 4%) was mainly responsible for early graft loss in the DCD cohort. These results from donors with broader acceptance criteria in age, body mass index, premortem interventions, etc. suggest that DCD pancreas grafts may have a larger application potential than previously recognized.