Serum procalcitonin in pneumococcal pneumonia in children
Serum procalcitonin in pneumococcal pneumonia in children
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DOI：
10.1183/09031936.01.17406230
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发表时间：
2001-04-01
影响因子：
24.3
通讯作者：
Remes, S
中科院分区：
文献类型：
--
作者：
Korppi, M;Remes, S
检测肺炎患儿血清降钙素原（PCT）是细菌感染的标志物，以检验PCT是否可以用于筛查肺炎球菌（PNC）和病毒性肺炎。患者人数为132人；平均年龄 3.0 岁，64% 为男性，所有病例均经放射学确诊，其中 46 例为肺泡性肺炎，86 例为间质性肺炎。通过一组针对 PNC、其他五种呼吸道细菌和七种常见呼吸道病毒的血清学检测来研究感染的病因。 PNC感染25例，病毒-PNC混合感染13例，病毒感染17例。一般来说，血清PCT与肺炎类型或病因无关。 40% 的 PNC 病例中 PCT 值 >1.0 mg.L-1，而病毒性或混合管型中的 PCT 值分别为 12-15%（p2 岁儿童比年龄较小的儿童。PNC 和病毒性肺炎筛查的临界限值为 0.5 ng.mL、10 ng . mL(-1) 和 2.0 ng . mL(-1)。最高灵敏度为 55%。 0.5 ng mL(-1) 截止水平，而在 1.0 ng mL(-1) 水平时达到最高特异性 88%，然而，阳性和阴性结果的似然比远非最佳。尽管肺炎球菌肺炎略高于病毒性肺炎，但血清降钙素原不能用于区分这两种类型的肺炎。
Serum procalcitonin (PCT), a marker of bacterial infection, was measured in children with pneumonia to examine whether PCT can be used to screen pneumococcal (PNC) from viral pneumonia.The number of patients was 132; mean age 3.0 yrs, and 64% were males, In all cases, pneumonia was radiologically confirmed, being alveolar in 46 and interstitial in 86 cases, The aetiology of infection was studied by a panel of serological tests for PNC, for five other respiratory bacteria and for seven common respiratory viruses. PNC infection was found in 25, mixed viral-PNC infections in 13 and viral infection in 17 cases.In general, serum PCT was not associated with the type or aetiology of pneumonia. PCT values were >1.0 mg.L-1 in 40% of PNC cases, as compared to 12-15% in viral or mixed casts, respectively (p2 yrs old children than in younger ones, The cut-off limits of 0.5 ng.mL 10 ng . mL(-1) and 2.0 ng . mL(-1) were tested for screening between PNC and viral pneumonia, The highest sensitivity of 55% was found at the 0.5 ng . mL(-1) cut-off level, whereas the highest specificity of 88% was reached at the level of 1.0 ng mL(-1). The likelihood ratios, however, were far from optimal for both the positive and negative results.Although marginally higher in pneumococcal pneumonia than in viral pneumonia, serum procalcitonin cannot be used to discriminate between these two types of pneumonia.