Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo
Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo
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DOI：
10.1161/01.cir.97.17.1695
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发表时间：
1998-05-05
期刊：
影响因子：
37.8
通讯作者：
Creager, MA
中科院分区：
文献类型：
--
作者：
Williams, SB;Goldfine, AB;Creager, MA
背景：糖尿病患者的内皮功能受损，然而，导致这种缺陷的因素目前尚不清楚。高血糖可使正常兔动脉内皮依赖性松弛在体外和大鼠小动脉在体内减弱。因此，本研究在体内检测了急性高血糖对非糖尿病人内皮依赖性血管舒张的影响。方法与结果：在动脉内输注50%葡萄糖达到局部高血糖（300 mg/dL）的6小时前和6小时内，通过肱动脉输注氯甲胆碱来评估内皮依赖性血管舒张，通过体积描图测定前臂血流量。在一组10名受试者中，与正常血糖相比，高血糖期间甲基苯丙胺介导的血管舒张有减弱的趋势(方差分析P= 0.07；最大反应，13.3+/-2.8 vs 14.7+/-1.5 mL。分钟(1)。100 mL（-1）。在这些受试者中，在葡萄糖输注期间，全身血清胰岛素水平显著升高（P.50）。结论-急性高血糖损害体内健康人内皮依赖性血管舒张。这一发现提示，血糖升高可能导致糖尿病患者内皮功能障碍。
Background-Endothelial function is impaired in patients with diabetes mellitus, However, the factors contributing to this defect are currently unknown. Hyperglycemia attenuates endothelium-dependent relaxation in normal rabbit arteries in vitro and rat arterioles in vivo. Accordingly, this study examined the effect of acute hyperglycemia on endothelium-dependent vasodilation in nondiabetic humans in vivo.Methods and Results-Endothelium-dependent vasodilation was assessed through brachial artery infusion of methacholine chloride both before and during 6 hours of local hyperglycemia (300 mg/dL) achieved by intra-arterial infusion of 50% dextrose, Forearm blood flow was determined by plethysmography, In a group of 10 subjects, there was a trend toward attenuated methacholine-mediated vasodilation during hyperglycemia compared with euglycemia (P=.07 by ANOVA; maximal response, 13.3+/-2.8 versus 14.7+/-1.5 mL . min(-1). 100 mL(-1), respectively). In these subjects, the systemic serum insulin levels increased significantly during the dextrose infusion (P.50),Conclusions-Acute hyperglycemia impairs endothelium-dependent vasodilation in healthy humans in vivo. This finding suggests that elevated glucose may contribute to the endothelial dysfunction observed in patients with diabetes mellitus.