CEFOXITIN AS A SINGLE-DOSE TREATMENT FOR URETHRITIS CAUSED BY PENICILLINASE-PRODUCING NEISSERIA-GONORRHOEAE
CEFOXITIN AS A SINGLE-DOSE TREATMENT FOR URETHRITIS CAUSED BY PENICILLINASE-PRODUCING NEISSERIA-GONORRHOEAE
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DOI：
10.1056/nejm197909063011001
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
MCCUTCHAN, JA
中科院分区：
文献类型：
--
作者：
BERG, SW;KILPATRICK, ME;MCCUTCHAN, JA
通过产生青霉素酶来抵抗标准青霉素方案的淋球菌现在在世界某些地区得到了很好的确立。由于头孢西丁是一种半合成的头孢霉素，在体外可抵抗淋球菌青霉素酶，因此在一个40%的分离株产生青霉素酶的地区，对普鲁卡因青霉素G和头孢西丁治疗淋病进行了比较。培养证实为淋球菌性尿道炎的男性[107]接受单剂量普鲁卡因青霉素G（480万U）或头孢西丁（2 g），肌肉注射。两组均口服丙磺舒1 g;头孢西丁与利多卡因一起给药以减轻注射部位疼痛。在青霉素酶阴性淋球菌感染的男性中，头孢西丁和青霉素都非常有效。77%的青霉素酶阳性菌株的男性使用青霉素失败，而头孢西丁完全成功。头孢西丁是一种有效的替代大观霉素的单次治疗由青霉素酶产生的N。淋病
Gonococci that resist standard penicillin regimens by production of a penicillinase are now well established in certain areas of the world. Because cefoxitin, a semisynthetic cephamycin, resists gonococcal penicillinase in vitro, procaine penicillin G and cefoxitin were compared in treatment of gonorrhea in an area where 40% of isolates produce penicillinase. Men [107] with culture-proved gonococcal urethritis were given a single dose of either procaine penicillin G, 4.8 million U, or cefoxitin, 2 g, i.m. Both groups took 1 g of probenecid orally; cefoxitin was given with lidocaine to reduce pain at the injection site. In men infected with penicillinase-negative gonococci, both cefoxitin and penicillin were highly effective. Penicillin failed in 77% of men with penicillinase-positive strains, whereas cefoxitin was completely successful. Cefoxitin is an effective alternative to spectinomycin for single-session therapy of urethritis caused by penicillinase-producing N. gonorrhoeae.