Regulation of intracellular and mitochondrial sodium in health and disease.
Regulation of intracellular and mitochondrial sodium in health and disease.
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DOI：
10.1161/circresaha.108.189050
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发表时间：
2009-02-13
影响因子：
20.1
通讯作者：
Eisner DA
中科院分区：
文献类型：
--
作者：
Murphy E;Eisner DA
The transmembrane sodium gradient is essential for both excitability of the cardiac cell and the regulation of the cytoplasmic concentrations of Ca and protons. In addition, movements of Na across the mitochondrial membrane affect matrix protons and calcium. In the first part of the review we discuss the most important pathways responsible for sarcolemmal and mitochondrial sodium movements. The bulk of the review considers the changes of intracellular Na concentration ([Na+]i) that occur in disease; specifically ischemia, reperfusion and heart failure. We review evidence implicating the increase of intracellular sodium to either increased influx of sodium (via either sodium channels or sodium-hydrogen exchange) or, alternatively, to decreased efflux on the Na-K pump. While much has been learnt about sodium regulation in the heart, there are still many unanswered questions, particularly concerning mitochondrial Na regulation.
