Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics.
Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics.
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DOI：
10.2147/hmer.s16316
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发表时间：
2012-05-08
期刊：
影响因子：
--
通讯作者：
Cabrera R
中科院分区：
文献类型：
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作者：
Dhanasekaran R;Limaye A;Cabrera R
肝细胞癌（HCC）是发展中国家常见的恶性肿瘤，其发病率在发展中国家呈上升趋势。这种癌症的流行病学是独特的，因为它的危险因素，包括丙型肝炎和B，已经明确确定。目前世界不同地区HCC发病率的变化趋势可以部分解释为肝炎患病率的变化。早期发现为HCC患者提供了治愈性治疗的唯一希望，因此针对高危患者的有效筛查策略至关重要。肝移植和手术切除仍然是治愈性治疗的基石。但是最近在局部区域治疗和分子靶向治疗晚期HCC方面取得了重大进展。在这篇综述中，讨论了目前世界范围内HCC的流行病学、监测、诊断、标准治疗和新兴疗法的趋势。
Hepatocellular carcinoma (HCC) is a common malignancy in developing countries and its incidence is on the rise in the developing world. The epidemiology of this cancer is unique since its risk factors, including hepatitis C and B, have been clearly established. The current trends in the shifting incidence of HCC in different regions of the world can be explained partly by the changing prevalence of hepatitis. Early detection offers the only hope for curative treatment for patients with HCC, hence effective screening strategies for high-risk patients is of utmost importance. Liver transplantation and surgical resection remains the cornerstone of curative treatment. But major advances in locoregional therapies and molecular-targeted therapies for the treatment of advanced HCC have occurred recently. In this review, current trends in the worldwide epidemiology, surveillance, diagnosis, standard treatments, and the emerging therapies for HCC are discussed.