RELATIONSHIP BETWEEN ANTISPERM ANTIBODIES AND TESTICULAR HISTOLOGIC-CHANGES IN HUMANS AFTER VASECTOMY
RELATIONSHIP BETWEEN ANTISPERM ANTIBODIES AND TESTICULAR HISTOLOGIC-CHANGES IN HUMANS AFTER VASECTOMY
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DOI：
10.1016/0090-4295(94)90246-1
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发表时间：
1994-04-01
期刊：
影响因子：
2.1
通讯作者：
MARSHALL, FF
中科院分区：
文献类型：
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作者：
JAROW, JP;GOLUBOFF, ET;MARSHALL, FF
Objective.确定输精管结扎男性睾丸组织学改变与抗精子抗体之间是否存在关联。方法.对19名输精管切除男性和21名生育对照者的睾丸活检标本进行形态测量。采用间接免疫磁珠法测定每位患者和对照组血清中的抗精子抗体状态。与对照组相比，输精管切除男性的曲细精管壁厚度（p <0.001）、局灶性间质纤维化（p < 0.001）和睾丸组织成分百分比（p < 0.01）显著增加。74%的输精管切除男性血清中存在抗精子活性，而对照组中无（p < 0.001）。睾丸组织学改变与免疫状态无关。输精管切除的男性表现出显着的睾丸组织学变化和增加自身免疫活性相比，生育的控制对象。这些组织学变化与抗精子抗体状态无直接关系，提示可能是其他病理生理过程所致。
Objective. To determine whether or not there is an association between testicular histologic changes and antisperm antibodies in vasectomized men. Methods. Morphometry was performed on testicular biopsy specimens obtained from 19 vasectomized men and 21 fertile control subjects. Antisperm antibody status was determined on the serum of each patient and control subject using the indirect immunobead assay.Results. Significant increases in seminiferous tubule wall thickness (p < 0.001), focal interstitial fibrosis (p < 0.001), and percent composition of interstitium (p < 0.01) were observed in vasectomized men as compared with control subjects. Serum antisperm activity was present in 74 percent of the vasectomized men but none in the control subjects (p < 0.001). There was no association between testicular histologic changes and immune status.Conclusions. Vasectomized men exhibit significant testicular histologic changes and increased autoimmune activity as compared with fertile control subjects. These histologic changes are not directly associated with antisperm antibody status, suggesting that some other pathophysiologic process must be responsible.