A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo
A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo
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DOI：
10.1128/iai.73.2.1260-1264.2005
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发表时间：
2005-02-01
影响因子：
3.1
通讯作者：
Titball, RW
中科院分区：
文献类型：
--
作者：
Essex-Lopresti, AE;Boddey, JA;Titball, RW
类鼻疽伯克霍尔德菌K96243基因组含有多个IV型菌毛蛋白相关基因座，包括一个编码推定菌毛结构蛋白（pilA）的基因座。pilA缺失突变体对人上皮细胞的粘附性降低，并且在线虫毒力模型和类鼻疽小鼠模型中毒性较低，表明IV型皮利在B中的作用。类鼻疽毒力
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.