Neurons of rostral ventrolateral medulla mediate somatic pressor reflex.
Neurons of rostral ventrolateral medulla mediate somatic pressor reflex.
复制标题
延髓头侧腹外侧神经元介导躯体升压反射。
DOI：
10.1152/ajpregu.1989.256.2.r448
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Reis,DJ
中科院分区：
文献类型：
--
作者：
Stornetta,RL;Morrison,SF;Ruggiero,DA;Reis,DJ
电刺激麻醉瘫痪大鼠坐骨神经或腓肠神经引起的躯体加压反射（SPR）使动脉压升高5 ~ 40 mmHg。从肌肉刺激股或胫传入神经产生降压反应。SPR不受脑桥中段横断的影响，但被消除的半切腰脊髓对侧，但不是同侧，刺激的神经或电解或红藻氨酸病变的对侧，但不是同侧，头端腹外侧延髓（RVL）。刺激臂丛神经引起SPR，对侧腰半切不能消除SPR，但RVL损伤可消除SPR。RVL病变始终重叠的领域含有苯乙醇胺N-甲基转移酶标记的C1肾上腺素能神经元。外侧网状核注射红藻氨酸对SPR无影响。无论是对侧或同侧电解病变的其他自主领域，包括臂旁核，孤束核，A5区，或小脑下脚（输出路径的LRN）的反射影响。在使用辣根过氧化物酶的轴突运输研究中，坐骨神经的传入终末与RVL中示踪剂注射逆行标记的背角中的脊髓网状神经元重叠。我们的结论是，SPR可以引起大鼠，它是由脊髓网状传入在对侧脊髓，RVL的C1肾上腺素能区是一个关键区域的整合的躯体加压反射。
The somatic pressor reflex (SPR) elicited in anesthetized paralyzed rats by electrical stimulation of the sciatic or sural cutaneous afferent nerves produced an increase in arterial pressure ranging from 5 to 40 mmHg. Stimulation of femoral or tibial afferent nerves from muscle produced a depressor response. The SPR was not affected by midpontine transection but was eliminated either by hemisection of the lumbar spinal cord contralateral, but not ipsilateral, to the stimulated nerve or by electrolytic or kainic acid lesion of the contralateral, but not ipsilateral, rostral ventrolateral medulla (RVL). Stimulation of the brachial plexus elicited an SPR that was not eliminated by contralateral lumbar hemisection but was abolished by RVL lesion. RVL lesions consistently overlapped areas containing phenylethanolamine N-methyltransferase-labeled C1 adrenergic neurons. Kainic acid injections into the lateral reticular nucleus (LRN) did not affect the SPR. Neither contralateral nor ipsilateral electrolytic lesions of other autonomic areas including parabrachial nucleus, the nucleus tractus solitarii, the A5 region, or the inferior cerebellar peduncle (output pathway of the LRN) affected the reflex. In axonal transport studies using horseradish peroxidase, afferent terminals of the sciatic nerve were shown to overlap spinoreticular neurons in the dorsal horn retrogradely labeled from tracer injections in the RVL. We conclude that the SPR can be elicited in rats, that it is mediated by spinoreticular afferents traveling in the contralateral spinal cord, and that the C1 adrenergic area of the RVL is a critical region for the integration of the somatic pressor reflex.