Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors.
Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors.
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DOI：
10.1186/1471-2407-8-237
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发表时间：
2008-08-14
期刊：
影响因子：
3.8
通讯作者：
Alshafie GA
中科院分区：
文献类型：
--
作者：
Harris RE;Beebe-Donk J;Alshafie GA
流行病学和实验室研究表明，阿司匹林和其他非甾体抗炎药（NSAID）对结肠癌具有化学预防作用，可能至少部分是由于其对环氧化酶-2（考克斯-2）（前列腺素级联反应的限速酶）的活性。我们进行了一项结肠癌病例对照研究，旨在比较选择性和非选择性考克斯-2抑制剂的作用。在2003-2004年期间，从俄亥俄州哥伦布的詹姆斯癌症医院共确定了326例结肠癌患者，并与652例无癌症史的对照组进行了比较，这些对照组与病例在年龄、种族和居住县方面的比例为2：1。使用标准化的风险因素调查问卷确定过去和现在使用处方药和非处方药以及结肠癌风险因素的数据。通过计算比值比（OR）和95%置信区间来量化考克斯-2抑制剂的作用。结果显示，选择性考克斯-2抑制剂（OR = 0.31，95%CI = 0.16-0.57）、常规阿司匹林（OR = 0.33，95%CI = 0.20-0.56）和布洛芬或萘普生（0.28，95%CI = 0.15-0.54）可显著降低风险。对乙酰氨基酚（一种考克斯-2活性可以忽略的化合物）和低剂量阿司匹林（81 mg）对结肠癌的风险没有显著影响。这些结果表明，无论是非选择性和选择性考克斯-2抑制剂产生显着降低结肠癌的风险，强调其强大的潜力，结肠癌的化学预防。
Epidemiologic and laboratory investigations suggest that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon cancer perhaps due at least in part to their activity against cyclooxygenase-2 (COX-2), the rate-limiting enzyme of the prostaglandin cascade. We conducted a case control study of colon cancer designed to compare effects of selective and non-selective COX-2 inhibitors. A total of 326 incident colon cancer patients were ascertained from the James Cancer Hospital, Columbus, Ohio, during 2003–2004 and compared with 652 controls with no history of cancer and matched to the cases at a 2:1 ratio on age, race, and county of residence. Data on the past and current use of prescription and over the counter medications and colon cancer risk factors were ascertained using a standardized risk factor questionnaire. Effects of COX-2 inhibiting agents were quantified by calculating odds ratios (OR) and 95% confidence intervals. Results showed significant risk reductions for selective COX-2 inhibitors (OR = 0.31, 95% CI = 0.16–0.57), regular aspirin (OR = 0.33, 95% CI = 0.20–0.56), and ibuprofen or naproxen (0.28, 95% CI = 0.15–0.54). Acetaminophen, a compound with negligible COX-2 activity and low dose aspirin (81 mg) produced no significant change in the risk of colon cancer. These results suggest that both non-selective and selective COX-2 inhibitors produce significant reductions in the risk of colon cancer, underscoring their strong potential for colon cancer chemoprevention.
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影响因子：
158.5
作者：
Bertagnolli, Monica M.;Eagle, Craig J.;Hawk, Ernest T.
通讯作者：
Hawk, Ernest T.
DOI：
10.1073/pnas.89.16.7384
发表时间：
1992-08-15
影响因子：
11.1
作者：
HLA, T;NEILSON, K
通讯作者：
NEILSON, K
影响因子：
158.5
作者：
Solomon, SD;McMurray, JJV;Bertagnolli, M
通讯作者：
Bertagnolli, M
影响因子：
120.7
作者：
Mukherjee, D;Nissen, SE;Topol, EJ
通讯作者：
Topol, EJ
影响因子：
2.8
作者：
White, WB;Faich, G;Lefkowith, JB
通讯作者：
Lefkowith, JB