Drug involvement in fatal overdoses
Drug involvement in fatal overdoses
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DOI：
10.1016/j.ssmph.2017.01.009
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发表时间：
2017-12-01
影响因子：
4.7
通讯作者：
Ruhm, Christopher J.
中科院分区：
文献类型：
--
作者：
Ruhm, Christopher J.
分析了多死因（MCOD）文件中的死亡证明数据，以更好地了解1999年至2014年期间致命过量增加的主要原因。使用统计调整方法来解释报告的药物参与发生的低估，因为死亡证明通常没有具体说明死亡涉及哪些药物。联合用药的频率引入了额外的不确定性，因此对任何药物与单独药物的参与进行了区分。许多结果对所选的开始和结束年份很敏感。从1999年开始的分析窗口期，类阿片镇痛剂在吸毒死亡增加中起主要作用，但其他毒品，特别是海洛因，在最近一段时间变得更加重要。复方药物的使用在所有时期都很重要，在制定减缓或扭转过量死亡增加的政策时需要考虑到这一点。
Death certificate data from the Multiple Cause of Death (MCOD) files were analyzed to better understand the drug categories most responsible for the increase in fatal overdoses occurring between 1999 and 2014. Statistical adjustment methods were used to account for the understatement in reported drug involvement occurring because death certificates frequently do not specify which drugs were involved in the deaths. The frequency of combination drug use introduced additional uncertainty and so a distinction was made between any versus exclusive drug involvement. Many results were sensitive to the starting and ending years chosen for examination. Opioid analgesics played a major role in the increased drug deaths for analysis windows starting in 1999 but other drugs, particularly heroin, became more significant for recent time periods. Combination drug use was important for all time periods and needs to be accounted for when designing policies to slow or reverse the increase in overdose deaths.