Treatment of lymphoma with adoptively transferred T cells.
Treatment of lymphoma with adoptively transferred T cells.
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DOI：
10.1517/14712590903260785
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发表时间：
2009-11
影响因子：
4.6
通讯作者：
Press OW
中科院分区：
文献类型：
--
作者：
Till BG;Press OW
Chemotherapy-resistant lymphomas can be cured with allogeneic hematopoietic cell transplantation, demonstrating the susceptibility of these tumors to T cell-mediated immune responses. However, high rates of transplant-related morbidity and mortality limit this approach. Efforts have therefore been made to develop alternative T cell-based therapies, and there is growing evidence that adoptive therapy with T cells targeted to lymphoma-associated antigens may be a safe and effective new method for treating this group of diseases. We review publications on adoptive therapy with ex-vivo-expanded T cells targeting viral antigens, as well as genetically modified autologous T cells, as strategies for the treatment of lymphoma, with the goal of providing an overview of these approaches. Epstein-Barr virus (EBV)-specific T cell therapy is an effective and safe method of treating EBV-associated lymphomas; however, most lymphoma subtypes do not express EBV antigens. For these diseases, adoptive immunotherapy with genetically modified T cells expressing chimeric T cell receptors targeting lymphoma-associated antigens such as CD19 and CD20 appears to be a promising alternative. Recent innovations including enhanced co-stimulation, exogenous cytokine administration, and use of memory T cells promise to overcome many of the limitations and pitfalls initially encountered with this approach.
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影响因子：
15.9
作者：
Berger, Carolina;Jensen, Michael C.;Riddell, Stanley R.
通讯作者：
Riddell, Stanley R.
影响因子：
20.3
作者：
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4.4
作者：
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Sung, YC
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6.5
作者：
Cheadle, EJ;Gilham, DE;Hawkins, RE
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Hawkins, RE
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20.3
作者：
Berger, C;Flowers, ME;Riddell, SR
通讯作者：
Riddell, SR