Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≧2 articular synovitis in rheumatoid arthritis: Retrospective observational study
Prediction of radiographic progression during a treat-to-target strategy by the sequential application of MRI-proven bone marrow oedema and power-Doppler grade ≧2 articular synovitis in rheumatoid arthritis: Retrospective observational study
复制标题
通过连续应用 MRI 证实的骨髓水肿和功率多普勒 ≥2 级关节滑膜炎来预测类风湿关节炎治疗目标策略期间的放射学进展：回顾性观察研究
DOI：
10.1093/mr/roac077
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发表时间：
2022
影响因子：
2.2
通讯作者：
Iwamoto Naoki et al.
中科院分区：
文献类型：
--
作者：
Takatani Ayuko;Tamai Mami;Ohki Nozomi;Okamoto Momoko;Endo Yushiro;Tsuji Sousuke;Shimizu Toshimasa;Umeda Masataka;Fukui Shoichi;Sumiyoshi Remi;Nishino Ayako;Koga Tomohiro;Kawashiri Shin-ya;Iwamoto Naoki et al.
目的探讨磁共振成像（MRI）和超声（US）联合应用对早期类风湿关节炎（RA）影像学进展的预测价值，并探讨MRI和US联合应用的时机。2010年至2017年在长崎大学医院招募，并接受了为期1年的靶向治疗策略治疗。MRI采用RA MRI评分法进行评价，US采用流变学临床试验结局指标进行评价。采用与MRI和US相同的方式，通过Genant改良的Sharp评分对症状侧的平片进行评估。影像学进展定义为1年时年增加≥0.75。分析与放射学进展相关的因素。还有，结果Logistic回归模型显示，基线和6个月时MRI证实的骨髓水肿和功率-3个月或6个月时Doppler分级≥2级的关节滑膜炎与1年时的放射学进展显著相关。早期RA患者的放射学进展。
ObjectivesTo investigate the appropriate timing, useful findings and combination of magnetic resonance imaging (MRI) and ultrasound (US) for predicting the radiographic progression in early rheumatoid arthritis (RA).MethodsForty-four active RA patients, who examined by both of MRI and US in the symptomatic wrist and finger joints, were recruited in Nagasaki University Hospital from 2010 to 2017 and treated by the treat-to-target therapeutic strategy for 1 year. MRI was evaluated by RA MRI scoring and US by Outcomes Measures in Rheumatology Clinical Trial, respectively. Plain radiographs were assessed by the Genant-modified Sharp score for the symptomatic side in the same manner as MRI and US. Radiographic progression was defined as an annual increase ≥0.75 at 1 year. Factors associated with radiographic progression were analysed. Also, the optimal combination of MRI and US at each timepoint was considered.ResultsLogistic regression model revealed that MRI-proven bone marrow oedema at baseline and 6 months and joint counts of power-Doppler grade ≥2 articular synovitis at 3 or 6 months were significantly associated with radiographic progression at 1 year.ConclusionThis study may suggest the favourable timing and combination of MRI and US at each point to predict radiographic progression in patients with early-stage RA.