MicroRNA dysregulation in melanoma
MicroRNA dysregulation in melanoma
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DOI：
10.1016/j.suronc.2016.05.017
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发表时间：
2016-09-01
影响因子：
2.3
通讯作者：
Carson, William E., III
中科院分区：
文献类型：
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作者：
Latchana, Nicholas;Ganju, Akaansha;Carson, William E., III
黑色素瘤是最致命的皮肤癌。当前黑色素瘤治疗面临的挑战包括准确预测对辅助治疗有反应的个体以及早期发现复发。这些和其他挑战促使人们对可用作诊断、预后和治疗辅助的生物标志物进行研究。 MicroRNA (miR) 是蛋白质翻译的小型 19-22 核苷酸 RNA 抑制剂。细胞内存在超过 800 种不同的 miR，重要的是，miR 表达谱可能因不同细胞类型和恶性肿瘤阶段而异。恶性黑色素瘤的独特表达谱已被描述；然而，这项工作尚未转化为常规临床实践。我们重点介绍涉及黑色素瘤肿瘤发生的常见 miR 的相关研究，包括 miR-21、miR-125b、miR-150、miR-155、miR-205 和 miR-211。特别是，重点放在黑色素瘤进展不同阶段的差异表达、预后影响和潜在的机制参与。集中精力抑制这些 miR 可能是将临床前努力转化为具有临床意义的应用的最有效方法。 (C) 2016 Elsevier Ltd. 保留所有权利。
Melanoma is the deadliest form of skin cancer. Current challenges facing the management of melanoma include accurate prediction of individuals who will respond to adjuvant therapies as well as early detection of recurrences. These and other challenges have prompted investigation into biomarkers that could be used as diagnostic, prognostic and therapeutic aids. MicroRNAs (miRs) are small 19-22 nucleotide RNA inhibitors of protein translation. Over 800 different miRs are present within cells and importantly miR expression profiles may vary across different cells types and stages of malignancy. Unique expression profiles have been described for malignant melanoma; however, this work has yet to be translated into routine clinical practice. We highlight pertinent studies involving common miRs implicated in the oncogenesis of melanoma including miR-21, miR-125b, miR-150, miR-155, miR-205, and miR-211. In particular, emphasis is placed upon differential expression across different stages of melanoma progression, prognostic implications and potential mechanistic involvement. Focused efforts on inhibition of these miRs could be the most efficient method of translating preclinical endeavors into clinically meaningful applications. (C) 2016 Elsevier Ltd. All rights reserved.