Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents
Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents
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DOI：
10.1016/s0167-7799(97)01167-0
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发表时间：
1998-04-01
影响因子：
17.3
通讯作者：
Peltz, SW
中科院分区：
文献类型：
--
作者：
Dinman, JD;Ruiz-Echevarria, MJ;Peltz, SW
许多病毒利用程序性核糖体移码来调节结构蛋白和酶蛋白的产生。改变移码效率会破坏病毒的生命周期，消除或减少病毒的产生，因此核糖体移码提供了一个独特的靶点，抗病毒药可以发挥作用，本文介绍了一系列快速检测策略，已开发和用于识别潜在的抗病毒药，目标程序性-1核糖体移码。
Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production, Ribosomal frameshifting therefore provides a unique target on which antiviral agents can function, This article describes a series of rapid assay strategies that have been developed and used to identify potential antiviral agents that target programmed -1 ribosomal frameshifting.