Recent vaccine technology in industrial animals.
Recent vaccine technology in industrial animals.
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DOI：
10.7774/cevr.2016.5.1.12
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发表时间：
2016-01
影响因子：
2.7
通讯作者：
Choi KM
中科院分区：
文献类型：
--
作者：
Kim H;Lee YK;Kang SC;Han BK;Choi KM
各种新技术已被应用于开发针对各种动物疾病的疫苗。病毒样颗粒（VLP）疫苗技术用于制造基于甲病毒载体的猪圆环病毒2型和RNA颗粒疫苗，用于猪流行性腹泻（PED）。虽然VLP被归类为灭活病毒疫苗，但由于其结构与原始病毒相似，因此它可以诱导长期和细胞介导的免疫。RNA颗粒疫苗使用委内瑞拉马脑炎（VEE）病毒基因作为载体。VEE病毒部分基因可被PED病毒刺突基因取代。重组疫苗可以通过取代VEE载体中的靶基因来产生。这两种新的疫苗技术使人们能够在相对较短的时间内有效地控制这种传染病。
Various new technologies have been applied for developing vaccines against various animal diseases. Virus-like particle (VLP) vaccine technology was used for manufacturing the porcine circovirus type 2 and RNA particle vaccines based on an alphavirus vector for porcine epidemic diarrhea (PED). Although VLP is classified as a killed-virus vaccine, because its structure is similar to the original virus, it can induce long-term and cell-mediated immunity. The RNA particle vaccine used a Venezuela equine encephalitis (VEE) virus gene as a vector. The VEE virus partial gene can be substituted with the PED virus spike gene. Recombinant vaccines can be produced by substitution of the target gene in the VEE vector. Both of these new vaccine technologies made it possible to control the infectious disease efficiently in a relatively short time.