Cytokine-producing mammary carcinomas in transgenic rats carrying the pX gene of human T-lymphotropic virus type I.
Cytokine-producing mammary carcinomas in transgenic rats carrying the pX gene of human T-lymphotropic virus type I.
复制标题
携带人类 T 淋巴细胞病毒 I 型 pX 基因的转基因大鼠中产生细胞因子的乳腺癌。
作者：
S. Yamada;H. Ikeda;H. Yamazaki;H. Shikishima;K. Kikuchi;A. Wakisaka;N. Kasai;K. Shimotohno;T. Yoshiki
在WKAH和F344两个品系的转基因大鼠(PX大鼠)中，携带人类T淋巴细胞趋化病毒I型PX基因的两个品系中，未分化乳腺癌主要发生在大约5个月大的雌性大鼠身上，肿瘤组织中有大量的粒细胞渗透。12个月龄时肿瘤发生率达40%左右。白介素8家族的粒细胞趋化因子Px和宿主基因Gro和MIP-2的mRNAs在肿瘤组织中高表达。由于一些癌基因和抑癌基因的表达和点突变尚未被证实，PX转基因可能在这些PX大鼠体内反式激活迄今未知的新的致癌途径。
In two lines of transgenic rats (pX rats) from WKAH and F344 strains and carrying the human T-lymphotropic virus type I pX gene, undifferentiated mammary carcinomas developed predominantly in females starting at about 5 months of age, and there was massive infiltration of granulocytes in the tumor tissue. The incidence of the tumor reached about 40% when the rats were 12 months old. mRNAs of both pX and host genes Gro and MIP-2, which are granulocyte chemoattractants of the interleukin 8 family, were highly expressed in the tumor tissue. Since expression and point mutation of several oncogenes and the antioncogene were not demonstrated, hitherto unidentified novel oncogenic pathways may be transactivated by the pX transgene in these pX rats.
影响因子：
4.4
作者：
U. Widmer;K. Manogue;A. Cerami;B. Sherry
通讯作者：
U. Widmer;K. Manogue;A. Cerami;B. Sherry
HTLV-1 转基因小鼠中氧化肌纤维的变性。
DOI：
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发表时间：
1989
期刊：
The American journal of pathology
影响因子：
--
作者：
Nerenberg,MI;Wiley,CA
通讯作者：
Wiley,CA