Intravascular myopericytoma: An interesting case of a long-standing large, painful subcutaneous tumor
Intravascular myopericytoma: An interesting case of a long-standing large, painful subcutaneous tumor
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DOI：
10.1111/j.1440-1827.2010.02628.x
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发表时间：
2011-03-01
影响因子：
2.2
通讯作者：
Park, Moon Hyang
中科院分区：
文献类型：
--
作者：
Ko, Joo Yeon;Choi, Won Jun;Park, Moon Hyang
肌周细胞瘤是一种良性肿瘤，由似乎与假定的血管周围肌样细胞有明显分化的细胞组成。在肌外皮细胞瘤中，血管内变异似乎很少被报道。一名67岁的男性，在其右大腿外侧皮下组织中有一个3 x 3.5 cm大小的缓慢生长的疼痛性肿块，有15年的病史。组织学研究显示皮下肿块完全位于静脉腔内。肿瘤由梭形肌样细胞组成，呈同心圆状排列，与薄壁血管通道密切相关。肿瘤细胞弥漫性平滑肌肌动蛋白阳性，CD34局灶性阳性，结蛋白和CD31阴性。根据这些发现，我们诊断此病变为血管内肌外皮细胞瘤。不像以前的报道，我们的病例显示了一个相对较大的疼痛性皮下肿块，尽管这个肿瘤具有血管内性质。
Myopericytoma is a benign neoplasm consisting of cells that appear to have a distinct differentiation towards presumed perivascular myoid cells. Amongst myopericytoma, an intravascular variant appears to have been reported only rarely. A 67-year-old man presented with a 15-year history of a painful, slow growing 3 x 3.5 cm sized mass in the subcutis of his right lateral thigh. Histopathological studies showed a subcutaneous mass entirely within the lumen of a vein. The tumor was composed of spindle-shaped myoid-appearing cells in a concentric arrangement, intimately associated with thin-walled vascular channels. Tumor cells were diffusely positive for smooth muscle actin, focally positive for CD34, and negative for desmin and CD31. From these findings, we diagnosed this lesion as intravascular myopericytoma. Unlike previous reports, our case showed a relatively large painful subcutaneous mass, although this tumor has an intravascular nature.