Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis -: A comparative multi-centre trial of 2 treatment approaches
Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis -: A comparative multi-centre trial of 2 treatment approaches
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DOI：
10.1034/j.1600-051x.2001.280806.x
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发表时间：
2001-08-01
影响因子：
6.7
通讯作者：
Garrett, S
中科院分区：
文献类型：
--
作者：
Wennström, JL;Newman, HN;Garrett, S
目的：在目前为期6个月的多中心试验中，评估了两种不同的非手术治疗慢性牙周炎的结果，两种方法都涉及使用局部给药的控释多西环素。材料和方法：来自3个中心的105例中晚期慢性牙周炎成年患者参加了试验。每位患者必须在2个颌骨象限中至少有8个牙周部位，探测袋深度（PPD）大于或等于5mm，并且在口袋探测（BoP）后出血，其中至少2个部位大于或等于7mm，另外2个部位大于或等于6mm。基线检查包括牙菌斑、PPD、临床附着水平（CAL）和BoP的评估，并给予口腔卫生方面的详细指导。然后将患者随机分配到两个治疗组中的一个：局部镇痛的刮治/根刨（SRP）或清创（无镇痛的龈上和龈下超声器械）。“SRP”组在局部镇痛下进行单次全口龈上/龈下刮治和牙根刨平。此外，在3个月的回顾访问中，使用超声器械进行全口龈上/龈下清创。随后在剩余PPD大于或等于5mm的部位龈下应用8.5% w/w的强力霉素聚合物。“清创”组患者首先使用超声仪进行45分钟的全口清创，不给予局部镇痛，随后在PPD大于或等于5mm的部位应用强力霉素。在第3个月，剩余PPD大于或等于5 mm的地点进行除垢和根刨。3个月和6个月复查。结果：在3个月时，“清创”组显示PPD小于或等于4 mm的部位比例明显高于“SRP”组(58%比50%
Aim: In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated.Material and methods: 105 adult patients with moderately advanced chronic periodontitis from 3 centres participated in the trial. Each patient had to present with at least 8 periodontal sites in 2 jaw quadrants with a probing pocket depth (PPD) of greater than or equal to5 mm and bleeding following pocket probing (BoP), out of which at least 2 sites had to be greater than or equal to7 mm and a further 2 sites greater than or equal to6 mm. Following a baseline examination, including assessments of plaque, PPD, clinical attachment level (CAL) and BoP, careful instruction in oral hygiene was given. The patients were then randomly assigned to one of two treatment groups: scaling/root planing (SRP) with local analgesia or debridement (supra- and subgingival ultrasonic instrumentation without analgesia). The "SRP" group received a single episode of full-mouth supra-/subgingival scaling and root planing under local analgesia. In addition, at a 3-month recall visit, a full-mouth supra-/subgingival debridement using ultrasonic instrumentation was provided. This was followed by subgingival application of an 8.5% w/w doxycycline polymer at sites with a remaining PPD of greater than or equal to5 mm. The patients of the "debridement" group were initially subjected to a 45-minute full-mouth debridement with the use of an ultrasonic instrument and without administration of local analgesia, and followed by application of doxycycline in sites with a PPD of greater than or equal to5 mm. At month 3, sites with a remaining PPD of greater than or equal to5 mm were subjected to scaling and root planing. Clinical re-examinations were performed at 3 and 6 months.Results: At 3 months, the proportion of sites showing PPD of less than or equal to4 mm was significantly higher in the "debridement" group than in the "SRP" group (58% versus 50%; p