Association between Ataxia Telangiectasia Mutated Gene Polymorphisms and Childhood Leukemia in Taiwan
Association between Ataxia Telangiectasia Mutated Gene Polymorphisms and Childhood Leukemia in Taiwan
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DOI：
10.4077/cjp.2011.amm106
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发表时间：
2011-12-31
影响因子：
1.8
通讯作者：
Bau, Da-Tian
中科院分区：
文献类型：
--
作者：
Wang, Chung-Hsing;Wu, Kang-Hsi;Bau, Da-Tian
共济失调毛细血管扩张突变（ataxia telangi扩张突变，ATM）基因在修复双链断裂和维持基因组稳定性中起重要作用。在本病例对照研究中，研究了7个ATM单核苷酸多态性（rs600931、rs189037、rs652311、rs624366、rs228589、rs227092和rs227060）与台湾儿童白血病风险的关系。对266名儿童白血病患者和266名年龄匹配的健康对照进行了基因分型和分析。7个ATM多态性基因型频率分布的p值分别为0.8925、0.2835、0.5772、0.8731、0.3641、0.9181和0.5071。7个ATM多态性等位基因频率分布的p值分别为0.6158、0.1179、0.6971、0.7944、0.1887、0.6605和0.2747。虽然该结果并未表明ATM多态性与儿童白血病直接相关，但ATM与其他因素的基因-基因和基因-环境相互作用值得未来进一步研究。
The ataxia telangiectasia mutated (ATM) gene plays a major role in repairing the double-strand breaks and maintaining the genome stability. In this case-control study, associations of seven ATM single-nucleotide polymorphisms (rs600931, rs189037, rs652311, rs624366, rs228589, rs227092 and rs227060) with risks in childhood leukemia in a Taiwanese population were investigated. Two hundred and sixty-six patients with childhood leukemia and 266 age-matched healthy controls recruited were genotyped and analyzed. The P-values of the distributions of the genotypic frequencies in the seven ATM polymorphisms were 0.8925, 0.2835, 0.5772, 0.8731, 0.3641, 0.9181 and 0.5071, respectively. The P-values of the distributions of the allelic frequencies in the seven ATM polymorphisms were 0.6158, 0.1179, 0.6971, 0.7944, 0.1887, 0.6605 and 0.2747, respectively. Although the results did not indicate that ATM polymorphism is directly associated with childhood leukemia, the gene-gene and gene-environment interactions of ATM with other factors is worthy of further investigation in the future.