Ketamine Suppression of Chemically Induced Convulsions in the Two‐Day‐Old White Leghorn Cockerel
Ketamine Suppression of Chemically Induced Convulsions in the Two‐Day‐Old White Leghorn Cockerel
复制标题
氯胺酮抑制两天龄白来航公鸡化学性惊厥
DOI：
10.1213/00000539-198006000-00003
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发表时间：
1980
影响因子：
5.7
通讯作者：
K. C. Troutman
中科院分区：
文献类型：
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作者：
B. Reder;L. Trapp;K. C. Troutman
氯胺酮在动物和人类中的惊厥特性已被评估，但结果相互矛盾。本研究在一个以前未见报道的动物模型中评价了氯胺酮的惊厥特性。两天大的雏鸟之所以被选为实验动物，是因为它们的血脑屏障不完整，因此对影响中枢神经系统的外来物质有更大的穿透力。对照组和实验动物被给予剂量水平(100 mg/kg)的中枢神经系统刺激剂戊四唑(Metrazol)，导致90%的动物惊厥。然后观察氯胺酮预处理对以下指标的影响：(1)动物惊厥次数；(2)惊厥发作时间；(3)死亡率。氯胺酮(100 mg/kg)显著减少惊厥动物数量，降低死亡率；10 mg/kg氯胺酮显著延长惊厥发作时间。这项研究并不支持氯胺酮是一种惊厥药的结论。氯胺酮在雏鸡模型中具有显著的抗惊厥作用。
Ketamine has been evaluated for convulsant properties in animals and humans with contradictory results. The present investigation evaluated the convulsant properties of ketamine in a previously unreported animal model. Two-day-old chicks were selected as test animals because they have incomplete blood-brain barriers and thus greater penetrance of xenobiotics affecting the central nervous system. Control and experimental animals were given a central nervous system stimulant, pentylenetetrazol (Metrazol) at a dosage level (100 mg/kg) causing convulsions in 90% of animals. The effect of ketamine pretreatment was then observed for the: (1) number of animals convulsing; (2) time of onset of convulsions; and (3) mortality. Ketamine (100 mg/kg) significantly decreased the number of animals that convulsed and decreased mortality; 10 mg/kg of ketamine significantly prolonged the time of onset of convulsions. This study does not support the conclusion that ketamine is a convulsant. Ketamine has significant anticonvulsant properties in the young chick model.