Multifunctional optically driven microrobot for realtime 3D bio-manipulation and imaging
Multifunctional optically driven microrobot for realtime 3D bio-manipulation and imaging
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DOI：
10.1109/memsys.2011.5734354
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发表时间：
2011-03
期刊：
影响因子：
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通讯作者：
M. Ikeuchi;K. Isozaki;K. Kyue;H. Sunabe;N. Shimada;H. Sasago;K. Ikuta
中科院分区：
文献类型：
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作者：
M. Ikeuchi;K. Isozaki;K. Kyue;H. Sunabe;N. Shimada;H. Sasago;K. Ikuta
我们一直致力于研究能够进行单细胞操作和液体中实时反作用力传感的光学驱动微型机器人。在本报告中，我们开发了三项关键技术来实现单个活细胞的 3D 操纵、成像和传感。 (1)用于长时间成像的荧光微型机器人。 (2)机器人的表面功能化，以有效捕获细胞。 (3)用于实时观察的3D操纵和成像系统。这些结果应该会催生集成的微型机器人系统，该系统可以远程操纵液体中的活细胞，以研究细胞间相互作用、细胞对机械刺激的反应，并将细胞组装成用于组织工程的 3D 结构。
We have been working on optically driven microrobots capable of single cell manipulation and real-time reaction force sensing in liquid. In this report, we have developed three key technologies to realize 3D manipulation, imaging and sensing of a single living cell. (1) Fluorescent microrobot for long time imaging. (2) Surface functionalization of the robot for effective capture of cells. (3) 3D manipulation and imaging system for realtime observation. These results should lead to integrated micro robotic system that can remotely manipulate living cells in liquid to study cell-cell interactions, cellular response to mechanical stimulation, and to assemble cells into 3D structures for tissue engineering.