Prevalence and prognosis of prodromal Alzheimer's disease as assessed by magnetic resonance imaging and (18) F-fluorodeoxyglucose-positron emission tomography in a community: reanalysis from the Osaki-Tajiri Project.
Prevalence and prognosis of prodromal Alzheimer's disease as assessed by magnetic resonance imaging and (18) F-fluorodeoxyglucose-positron emission tomography in a community: reanalysis from the Osaki-Tajiri Project.
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通过磁共振成像和 (18) F-氟脱氧葡萄糖-正电子发射断层扫描在社区中评估前驱阿尔茨海默病的患病率和预后：Osaki-Tajiri 项目的重新分析。
DOI：
10.1111/psyg.12131
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tashiro M.
中科院分区：
文献类型：
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作者：
Meguro K;Akanuma K;Meguro M;Yamaguchi S;Ishii H;Tashiro M.
背景Duboiset al.提出了前驱期阿尔茨海默病（AD）的标准，以在其非常早期的阶段检测痴呆。由于检测需要磁共振成像和18 F-氟脱氧葡萄糖-正电子发射断层扫描（PET），患病率和预后尚未得到充分调查。MethodsOur数据库包括346名健康参与者（临床痴呆评分（CDR）0），119可疑痴呆（CDR 0.5），和32痴呆参与者（CDR 1+），并适用于调查前驱AD的患病率。随机选择44名CDR 0.5的受试者（37%）接受18 F-氟脱氧葡萄糖-PET。采用相同的百分比选择128名CDR 0和12名CDR 1 +参与者（总计：n= 184）来计算患病率。神经放射科医生根据Silvermanet等人的标准以盲态方式对PET图像进行分类。参与者被认为有前驱AD，如果他们表现出'顶叶/颞叶+/-额叶代谢减退'（PET）与海马atrophy（磁共振成像）。Results 18 CDR 0.5参与者（40.9%）符合前驱AD的标准，这是一个患病率为9.8%，年龄≥65岁的老年人。13前驱AD参与者（72%）转换为AD在5年的随访period.DiscussionThe前驱AD的概念和标准是有用的预测在一个社区的主题将转换为AD。
BackgroundDuboiset al. proposed the criteria for prodromal Alzheimer's disease (AD) to detect dementia in its very early stage. Because detection requires magnetic resonance imaging and18F‐fluorodeoxyglucose‐positron emission tomography (PET), the prevalence and prognosis have not been fully investigated.MethodsOur database included 346 healthy participants (Clinical Dementia Rating (CDR) 0), 119 with questionable dementia (CDR 0.5), and 32 dementia participants (CDR 1+) and was applied to investigate the prevalence of prodromal AD. Forty‐four CDR 0.5 participants (37%) were randomly selected to undergo18F‐fluorodeoxyglucose‐PET. The same percentage was applied to select 128 CDR 0 and 12 CDR 1 + participants (total:n= 184) to calculate the prevalence. A neuroradiologist classified the PET images in a blinded manner based on the criteria of Silvermanet al. Participants were considered to have prodromal AD if they exhibited ‘parietal/temporal +/− frontal hypometabolism’ (PET) with hippocampal atrophy (magnetic resonance imaging).ResultsEighteen CDR 0.5 participants (40.9%) met the criteria for prodromal AD, which was a prevalence rate of 9.8% among older adults aged ≥65 years. Thirteen prodromal AD participants (72%) converted to AD during the 5‐year follow‐up period.DiscussionThe concept and criteria for prodromal AD are useful for predicting which subjects in a community will convert to AD.