The UK DNA banking network: a "fair access" biobank
The UK DNA banking network: a "fair access" biobank
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DOI：
10.1007/s10561-009-9150-3
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发表时间：
2010-08-01
影响因子：
1.5
通讯作者：
Ollier, William
中科院分区：
文献类型：
--
作者：
Yuille, Martin;Dixon, Katherine;Ollier, William
英国DNA库网络（UDBN）是一个二级生物库：它汇集和管理来自他人的资源（样本和数据）。该网络一方面包括由临床医生领导的研究小组，每个小组都有不同的疾病专长，另一方面还包括管理样本和数据的研究基础设施。该基础设施解决了以下问题：提供有质量保证的安全样本采集、储存、补充和分发能力，以及便利获取DNA等分试样和数据，用于新的遗传流行病学同行审查研究。“公平获取”的原则和实践已经务实地发展，不像在这一领域的开放获取政策，是不麻烦的，而是适合加快新的研究设计和实施的目的。到目前为止，UDBN已经分发了超过60，000个样本用于主要的基因分型研究，产生了超过100亿个基因型。它提供了一个工作模式，可以为国家、欧洲和国际生物库的进展提供信息。
The UK DNA Banking Network (UDBN) is a secondary biobank: it aggregates and manages resources (samples and data) originated by others. The network comprises, on the one hand, investigator groups led by clinicians each with a distinct disease specialism and, on the other hand, a research infrastructure to manage samples and data. The infrastructure addresses the problem of providing secure quality-assured accrual, storage, replenishment and distribution capacities for samples and of facilitating access to DNA aliquots and data for new peer-reviewed studies in genetic epidemiology. 'Fair access' principles and practices have been pragmatically developed that, unlike open access policies in this area, are not cumbersome but, rather, are fit for the purpose of expediting new study designs and their implementation. UDBN has so far distributed > 60,000 samples for major genotyping studies yielding > 10 billion genotypes. It provides a working model that can inform progress in biobanking nationally, across Europe and internationally.