Sensitivity of visual evoked potentials and spectral domain optical coherence tomography in early relapsing remitting multiple sclerosis
Sensitivity of visual evoked potentials and spectral domain optical coherence tomography in early relapsing remitting multiple sclerosis
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DOI：
10.1016/j.msard.2016.12.005
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发表时间：
2017-02-01
影响因子：
4
通讯作者：
Alroughani, Raed
中科院分区：
文献类型：
--
作者：
Behbehani, Raed;Ahmed, Samar;Alroughani, Raed
背景：视觉诱发电位和频域光学相干断层扫描是常见的辅助研究，分别从功能和结构方面评估视觉通路。目的：比较复发缓解型多发性硬化症（RRMS）患者视觉诱发电位（VEP）和频域光学相干断层扫描（SDOCT）异常的发生率。方法：横断面研究 对 100 只眼睛的研究，这些眼睛自诊断以来病程不超过 5 年。研究了视网膜神经纤维层和神经节细胞/内丛状层与模式反转视觉诱发电位振幅和潜伏期以及对比敏感度的相关性。结果：所有眼睛中模式反转视觉VEP异常发生率为56%，而SOCT异常发生率为48%。平均 RNFL（r=-0.34，p=0.001）和 GCIPL（r=-0.39，p < 0.001）与 VEP 潜伏期之间存在显着负相关。在既往患有视神经炎的眼睛中，平均 RNFL（r=-0.33，p=0.037）和 GCIPL（r=-0.40，p=0.010）与 VEP 潜伏期之间存在显着负相关。 结论：我们发现，在早期复发缓解型多发性硬化症中，VEP 异常的患病率高于 SCOCT。这表明VEP对于检测早期RRMS患者视觉通路病变具有较高的敏感性。
Background: Visual evoked potentials and spectral-domain optical coherence tomography are common ancillary studies that assess the visual pathways from a functional and structural aspect, respectively.Objective: To compare prevalence of abnormalities of Visual evoked potentials (VEP) and spectral-domain optical coherence tomography (SDOCT) in patients with relapsing remitting multiple sclerosis (RRMS).Methods: A cross-sectional study of 100 eyes with disease duration of less than 5 years since the diagnosis. Correlation between retinal nerve fiber layer and ganglion-cell/inner plexiform layer with pattern-reversal visual evoked potentials amplitude and latency and contrast sensitivity was performed.Results: The prevalence of abnormalities in pattern-reversal visual VEP was 56% while that of SOCT was 48% in all eyes. There was significant negative correlations between the average RNFL (r=-0.34, p=0.001) and GCIPL (r=-0.39, p < 0.001) with VEP latency. In eyes with prior optic neuritis, a significant negative correlation was seen between average RNFL (r=-0.33, p=0.037) and GCIPL (r=-0.40, p=0.010) with VEP latency.Conclusions: We have found higher prevalence of VEP abnormalities than SCOCT in early relapsing-remitting multiple sclerosis. This suggests that VEP has a higher sensitivity for detecting lesions of the visual pathway in patients with early RRMS.