Serum and urinary cytokine levels of SLE patients
Serum and urinary cytokine levels of SLE patients
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DOI：
10.1691/ph.2012.1694
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发表时间：
2012-05-01
期刊：
影响因子：
1.6
通讯作者：
Zeher, M.
中科院分区：
文献类型：
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作者：
Brugos, B.;Vincze, Z.;Zeher, M.
系统性红斑狼疮(SLE)是一种慢性、复发性、多系统的自身免疫性疾病，临床表现多样。系统性红斑狼疮患者的预后受神经精神和肾脏损害的影响。40%-60%的患者存在狼疮性肾炎(LN)。传统的实验室参数在预测肾脏红斑方面并不敏感和特异，在过去的几年里，人们对寻找预测未来红斑狼疮的新的狼疮生物标志物越来越感兴趣。检测36例狼疮性肾炎患者(女34例，男2例，平均年龄：43.36±11.53岁)、23例无肾损害的SLE患者(女19例，男4例，平均年龄54±8.71岁)和30例健康对照(女23例，男7例，平均年龄45.5±12.4岁)的血、尿细胞因子水平。血清IL-1(IL-1)、IL-2(P
Systemic lupus erythematosus (SLE) is a chronic, relapsing, polysystemic autoimmune disease with various clinical signs. The prognosis of SLE patients is influenced by neuropsychiatric and renal involvement. Lupus nephritis (LN) is present in 40-60% of patients. Classical laboratory parameters are not sensitive and specific in prediction renal flares, over the last few years there has been a growing interest in searching novel lupus biomarkers predicting future flares. Our goal was to detect serum and urinary level of cytokines in 36 patients with lupus nephritis (34 female and 2 male, mean age: 43.36 +/- 11.53 years), 23 patients with SLE without renal involvement (19 women and 4 men, mean age: 54 +/- 8.71) (both groups followed by the 3rd Department of Internal Medicine, Division of Clinical Immunology, University of Debrecen) and 30 healthy controls (23 female and 7 male, mean age: 45.5 +/- 12.4). Serum IL-1 (interleukin), IL-2 (both p