Neuromodulatory Control of Long-Term Behavioral Patterns and Individuality across Development
Neuromodulatory Control of Long-Term Behavioral Patterns and Individuality across Development
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DOI：
10.1016/j.cell.2017.10.041
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发表时间：
2017-12-14
期刊：
影响因子：
64.5
通讯作者：
Bargmann, Cornelia I.
中科院分区：
文献类型：
--
作者：
Stern, Shay;Kirst, Christoph;Bargmann, Cornelia I.
动物在整个发育过程中产生复杂的行为模式，这些模式可能是个体共有的或独特的。在这里，我们研究的发展计划和个体差异的行为的贡献，通过监测单一的秀丽隐杆线虫在其完整的发展轨迹和量化他们的行为在高时空分辨率。这些测量结果揭示了可重复的轨迹自发觅食行为的定型内和之间的发展阶段。多巴胺、5-羟色胺、神经肽受体NPR-1和TGF-β肽NPR-7都对行为轨迹具有阶段特异性影响，这意味着存在由神经调质控制的模块化时间程序。此外，在受控环境中长大的同基因群体中的一小部分个体具有一致的、非遗传的行为偏差，这些偏差在整个发育过程中持续存在。一些神经调节系统增加或减少非遗传个体的程度，以塑造整个人群的持续行为模式。
Animals generate complex patterns of behavior across development that may be shared or unique to individuals. Here, we examine the contributions of developmental programs and individual variation to behavior by monitoring single Caenorhabditis elegans nematodes over their complete developmental trajectories and quantifying their behavior at high spatiotemporal resolution. These measurements reveal reproducible trajectories of spontaneous foraging behaviors that are stereotyped within and between developmental stages. Dopamine, serotonin, the neuropeptide receptor NPR-1, and the TGF-beta peptide DAF-7 each have stage-specific effects on behavioral trajectories, implying the existence of a modular temporal program controlled by neuromodulators. In addition, a fraction of individuals within isogenic populations raised in controlled environments have consistent, non-genetic behavioral biases that persist across development. Several neuromodulatory systems increase or decrease the degree of non-genetic individuality to shape sustained patterns of behavior across the population.